Zhu Wanlong, Fu Liya, Xu Changjing, Peng Ke, Liu Yuanzhi, Tang Hui, Huang Yilan, Yang Xuping
Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
School of Pharmacy, Southwest Medical University, Luzhou, China.
Front Pharmacol. 2022 Sep 6;13:978019. doi: 10.3389/fphar.2022.978019. eCollection 2022.
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder syndrome characterized by polycystic ovary, ovulation disorder and hyperandrogenemia, and is often accompanied by metabolic disorders. Enoxacin has been reported to protect against diet-induced obesity and insulin resistance by promoting fat thermogenesis. However, the function of enoxacin in PCOS remains unknown. This study aimed to investigate the impact of the enoxacin on the regulation of PCOS mouse model induced by dehydroepiandrosterone (DHEA). Here, we found that reproductive endocrine disorder, glucose intolerance, and ovarian dysfunction in PCOS mice induced by DHEA were attenuated by enoxacin treatment. Mechanistically, we identified that enoxacin can promote white fat browning and improve metabolic disorders, thus ameliorating DHEA-induced reproductive dysfunction. Moreover, these beneficial effects might be associated with the restoration of gut dysbiosis. These findings provide a novel therapeutic target for enoxacin in the treatment of PCOS.
多囊卵巢综合征（PCOS）是一种复杂的内分泌紊乱综合征，其特征为多囊卵巢、排卵障碍和高雄激素血症，且常伴有代谢紊乱。据报道，依诺沙星可通过促进脂肪产热来预防饮食诱导的肥胖和胰岛素抵抗。然而，依诺沙星在PCOS中的作用尚不清楚。本研究旨在探讨依诺沙星对脱氢表雄酮（DHEA）诱导的PCOS小鼠模型调节的影响。在此，我们发现依诺沙星治疗可减轻DHEA诱导的PCOS小鼠的生殖内分泌紊乱、葡萄糖不耐受和卵巢功能障碍。从机制上讲，我们确定依诺沙星可促进白色脂肪棕色化并改善代谢紊乱，从而改善DHEA诱导的生殖功能障碍。此外，这些有益作用可能与肠道菌群失调的恢复有关。这些发现为依诺沙星治疗PCOS提供了一个新的治疗靶点。
