Widerlöv E, Bissette G, Nemeroff C B
Neurosci Lett. 1987 Jun 26;77(3):311-5. doi: 10.1016/0304-3940(87)90519-2.
Neurotensin (NT), a tridecapeptide with a widespread and uneven distribution within the central nervous system of mammals, is known to be involved in a variety of physiological, behavioral, endocrine and biochemical functions. Groups of rats and mice were given i.p. injections of pentobarbital followed by intracisternal administration of NT or saline. Following decapitation, the plasma, liver and brain concentrations of pentobarbital were measured with a gas chromatographic/mass fragmentographic method. In the mice, but not in the rats, the NT injection caused a substantial inhibition of the pentobarbital metabolism and a prolongation of the sleeping time. The mechanism(s) behind this inhibition still remains unclear.
神经降压素（NT）是一种十三肽，在哺乳动物中枢神经系统中分布广泛且不均匀，已知它参与多种生理、行为、内分泌和生化功能。给大鼠和小鼠腹腔注射戊巴比妥，随后脑池内注射神经降压素或生理盐水。断头后，用气相色谱/质谱碎片分析法测定血浆、肝脏和脑中戊巴比妥的浓度。在小鼠中，而非大鼠中，注射神经降压素导致戊巴比妥代谢受到显著抑制，睡眠时间延长。这种抑制背后的机制仍不清楚。
