大鼠对中枢给予神经降压素的低温反应的个体发生。

Ontogeny of the hypothermic response to centrally administered neurotensin in rats.

作者信息

Hernandez D E, Nemeroff C B, Prange A J

出版信息

Brain Res. 1982 Mar;255(3):497-501. doi: 10.1016/0165-3806(82)90016-5.

Abstract

Neurotensin (NT), an endogenous tridecapeptide, when given intracisternally (i.c.) elicits significant hypothermia in a variety of mammals. The present study was designed to test the ability of centrally administered NT to induce a hypothermic effect in rats at different ages. Intracisternally administered NT (10 and 30 microgram) produced a marked dose-dependent hypothermia in rats aged 5, 10, 20, 30 and 60 days. This study confirms and extends the previously reported hypothermic effect of centrally administered NT in the rat and documents the responsiveness of young animals to the peptide.

摘要

神经降压素（NT）是一种内源性十三肽，当经脑池内（i.c.）给药时，可在多种哺乳动物中引起显著的体温过低。本研究旨在测试中枢给予NT对不同年龄大鼠诱导体温过低效应的能力。脑池内给予NT（10微克和30微克）可在5日龄、10日龄、20日龄、30日龄和60日龄的大鼠中产生显著的剂量依赖性体温过低。本研究证实并扩展了先前报道的中枢给予NT在大鼠中的体温过低效应，并证明了幼龄动物对该肽的反应性。