Office of Academic Research, Renmin Hospital of Wuhan University, Wuhan, China.
Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.
Front Public Health. 2022 Sep 6;10:976221. doi: 10.3389/fpubh.2022.976221. eCollection 2022.
The association of IFN-γ receptor 1 (IFNGR1) gene polymorphisms with tuberculosis (TB) susceptibility has not been systematically studied. We therefore conducted a meta-analysis to assess their association. Literature search was conducted in PubMed, EMBASE, Web of Science, and the Cochrane Library. Odds ratio (OR) and 95% confidence interval (CI) was pooled by the random-effect model. Statistical analyses were performed using STATA 12.0 software. Fourteen studies involved 7,699 TB cases and 8,289 controls were included in this meta-analysis. A significant association was found between the IFNGR1 rs2234711 polymorphism and TB susceptibility among Africans in dominant model (OR = 1.24, 95%CI:1.01-1.52), and among Asians in allele model (OR = 0.89, 95%CI: 0.79-0.99), homozygote model (OR = 0.82, 95%CI: 0.70-0.98) and additive model (OR = 0.90, 95%CI: 0.83-0.97). In addition, a significant association was observed between the IFNGR1 rs7749390 polymorphism and TB susceptibility among Africans in allele model (OR = 0.89, 95%CI: 0.82-0.98). No significant association was found between the IFNGR1 rs1327474 polymorphism and TB susceptibility. In summary, IFNGR1 rs2234711 polymorphism was associated with increased TB susceptibility in Africans and decreased TB susceptibility in Asians, while IFNGR1 rs7749390 polymorphism was associated with decreased TB susceptibility in Africans.
干扰素-γ 受体 1（IFNGR1）基因多态性与结核病（TB）易感性的关联尚未得到系统研究。因此，我们进行了一项荟萃分析来评估它们的相关性。在 PubMed、EMBASE、Web of Science 和 Cochrane Library 中进行了文献检索。使用随机效应模型汇总了比值比（OR）和 95%置信区间（CI）。使用 STATA 12.0 软件进行统计分析。这项荟萃分析纳入了 14 项研究，共涉及 7699 例 TB 病例和 8289 例对照。结果显示，IFNGR1 rs2234711 多态性与非洲人群的 TB 易感性在显性模型（OR=1.24，95%CI：1.01-1.52）、亚洲人群的等位基因模型（OR=0.89，95%CI：0.79-0.99）、纯合子模型（OR=0.82，95%CI：0.70-0.98）和加性模型（OR=0.90，95%CI：0.83-0.97）中存在显著相关性。此外，IFNGR1 rs7749390 多态性与非洲人群的 TB 易感性在等位基因模型（OR=0.89，95%CI：0.82-0.98）中也存在显著相关性。IFNGR1 rs1327474 多态性与 TB 易感性无显著相关性。总之，IFNGR1 rs2234711 多态性与非洲人群的 TB 易感性增加和亚洲人群的 TB 易感性降低相关，而 IFNGR1 rs7749390 多态性与非洲人群的 TB 易感性降低相关。
