Koss M C, Christensen H D, Bernthal P J, Gherezghiher T
Ophthalmic Res. 1987;19(2):113-9. doi: 10.1159/000265482.
Superior cervical ganglionectomy (SCG) produced delayed mydriasis and ocular hypotension in rabbits. Norepinephrine (NE) was lost from the iris-ciliary body exponentially with onset of about 11 h. NE in aqueous humor peaked at twice control levels (from 7 to 14 ng/ml) at 16.5 h and subsequently declined to below control levels by 24 h. Intracameral administration of radiolabeled NE (150 ng) to control eyes resulted in a calculated outflow of 1.6 microliter/min, comparable to that seen with fluorescein (1.7 microliter/min). NE administered to ganglionectomized eyes (26 h after surgery) resulted in a calculated outflow of 3.1 microliter/min. These results suggest that mydriasis following SCG may be due to NE released from degenerating sympathetic nerve endings. However, NE concentration in the aqueous humor appears inadequate to produce the delayed increase in outflow observed in rabbits after SCG.
颈上神经节切除术（SCG）可导致家兔出现迟发性瞳孔散大和眼压降低。随着约11小时的起始时间，虹膜睫状体中的去甲肾上腺素（NE）呈指数级减少。房水中的NE在16.5小时达到对照水平的两倍（从7至14纳克/毫升）峰值，随后在24小时降至对照水平以下。向对照眼房内注射放射性标记的NE（150纳克），计算得出流出率为1.6微升/分钟，与荧光素的流出率（1.7微升/分钟）相当。向神经节切除术后26小时的眼睛注射NE，计算得出流出率为3.1微升/分钟。这些结果表明，SCG后的瞳孔散大可能是由于变性交感神经末梢释放的NE所致。然而，房水中的NE浓度似乎不足以产生SCG后家兔观察到的流出延迟增加。
