阿司匹林和维生素E对小牛晶状体匀浆中相分离的影响。

Effect of aspirin and vitamin E on phase separation in calf lens homogenate.

作者信息

Eccarius S, Clark J I

出版信息

Ophthalmic Res. 1987;19(2):65-71. doi: 10.1159/000265475.

Abstract

Vitamin E (d-alpha-tocopherol) and aspirin were evaluated for their effects on the phase separation temperature, Tc, of calf lens cytoplasm. Vitamin E and aspirin were added to nuclear homogenate and the change in Tc was measured. Aspirin had no measurable effect on Tc. Vitamin E lowered Tc at a rate of -22 degrees C M-1 l-1. The results suggest that the effects of aspirin on cataract are unrelated to phase separation and that vitamin E may act on the phase separation in precataractous lens cells.

摘要

对维生素E（d-α-生育酚）和阿司匹林对小牛晶状体细胞质相分离温度（Tc）的影响进行了评估。将维生素E和阿司匹林添加到细胞核匀浆中，并测量Tc的变化。阿司匹林对Tc没有可测量的影响。维生素E以-22℃·M⁻¹·l⁻¹的速率降低Tc。结果表明，阿司匹林对白内障的影响与相分离无关，而维生素E可能作用于白内障前期晶状体细胞的相分离。