Department of Pathology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India.
Department of Pathology and Head and Neck Oncology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India.
J Cancer Res Ther. 2022 Jul-Sep;18(4):1036-1041. doi: 10.4103/jcrt.jcrt_786_21.
Tumor microenvironment plays an important role in cancer progression. Platelets are one of the components of the tumor environment shown to have a role in cancer survival and progression.
Ninety-six cases of squamous cell carcinoma (SCC) cases of the oral cavity and 96 age/sex-matched healthy controls were considered for the study. Data regarding platelet count, platelet distribution width (PDW), mean platelet volume (MPV), Platelet-Large Cell Ratio (P-LCR), Plateletcrit (PCT), platelet/neutrophil ratio (PNR), platelet/lymphocyte ratio (PLR), and Platelet/Monocyte Ratio (PNR) from automated hematology analyzer records and clinicopathological data from the Department of Pathology were captured. These data were compared between cases and controls and also with tumor size, tumor grade, lymph node status, and tumour node metastasis (TNM) stage of cases.
Mean ± standard deviation for platelet count, PDW, MPV, P-LCR, PCT, PNR, PLR and PMR among cases were 315.03 ± 98.26, 10.94 ± 1.66, 9.91 ± 0.77, 23.52 ± 5.64, 0.31 ± 0.086, 62.55 ± 31.51, 149.34 ± 61.32, and 498.67 ± 194.91, respectively, and among controls were 287.88 ± 74.11, 10.84 ± 1.18, 9.89 ± 0.72, 23.45 ± 4.55, 0.29 ± 0.061, 60.27 ± 21.02, 138.71 ± 49.28, and 497.64 ± 172.28, respectively. The association between means of platelet count, PDW, P-LCR, and PCT among cases and controls were statistically significant (P = 0.020, 0.006, 0.030, and 0.000, respectively). No statistically significant association was found between means of platelet count, PDW, MPV, P-LCR, PCT, PNR, PLR, and PMR versus tumor size, lymph node status, and tumor grades. The association between the means of PCT/PMR and TNM Stages I and II were statistically significant (P = 0.029 and 0.016, respectively).
Platelet count, morphology, and functions are altered in oral SCC. Platelet activation plays an important role in oral cancer. PCT and PMR can be used to predict the progress of oral SCC as a cost-effective inflammatory marker.
肿瘤微环境在癌症进展中起着重要作用。血小板是肿瘤环境的组成部分之一，据报道其在癌症的存活和进展中具有作用。
本研究纳入了 96 例口腔鳞状细胞癌（SCC）病例和 96 例年龄/性别匹配的健康对照者。从自动血液学分析仪记录中获取血小板计数、血小板分布宽度（PDW）、平均血小板体积（MPV）、血小板大细胞比（P-LCR）、血小板压积（PCT）、血小板/中性粒细胞比（PNR）、血小板/淋巴细胞比（PLR）和血小板/单核细胞比（PMN），并结合病理学部门的临床病理数据。比较病例和对照组之间以及病例的肿瘤大小、肿瘤分级、淋巴结状态和肿瘤淋巴结转移（TNM）分期之间的这些数据。
病例的血小板计数、PDW、MPV、P-LCR、PCT、PNR、PLR 和 PMR 的平均值±标准差分别为 315.03±98.26、10.94±1.66、9.91±0.77、23.52±5.64、0.31±0.086、62.55±31.51、149.34±61.32 和 498.67±194.91，对照组分别为 287.88±74.11、10.84±1.18、9.89±0.72、23.45±4.55、0.29±0.061、60.27±21.02、138.71±49.28 和 497.64±172.28。病例和对照组之间血小板计数、PDW、P-LCR 和 PCT 的平均值之间的关联具有统计学意义（P=0.020、0.006、0.030 和 0.000）。在病例中，血小板计数、PDW、MPV、P-LCR、PCT、PNR、PLR 和 PMR 与肿瘤大小、淋巴结状态和肿瘤分级之间无统计学显著关联。PCT/PMN 与 TNM 分期 I 和 II 的平均值之间存在统计学显著关联（P=0.029 和 0.016）。
口腔 SCC 中血小板的计数、形态和功能发生改变。血小板的激活在口腔癌中起着重要作用。PCT 和 PMR 可用作一种具有成本效益的炎症标志物来预测口腔 SCC 的进展。
