The Center of Laboratory Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
J Clin Lab Anal. 2020 Jul;34(7):e23295. doi: 10.1002/jcla.23295. Epub 2020 Mar 13.
Platelets play a role in tumor cell growth, metastasis, and angiogenesis, and the present study aimed to evaluate diagnostic and prognostic values of platelet parameters in patients with gynecological tumors.
A total of 1062 women were included. Differences of platelet parameters (platelet count [PLT], plateletcrit [PCT], mean platelet volume [MPV], platelet-large cell rate [P-LCR], and platelet distribution width [PDW]) between different categories were analyzed by nonparametric test. The optimal cutoff value was calculated with receiver operating characteristic analysis. Overall survivals were analyzed with Kaplan-Meier method and log-rank tests for univariate analysis.
Platelet count and PCT were significantly increased, and MPV and P-LCR were significantly reduced in malign and benign gynecological tumor groups compared with the controls (P < .001); PDW had no significant differences. There were no significant differences in PLT, PCT, MPV, P-LCR, and PDW between different tumor locations and pathologic types. The optimal cutoff values of PLT, PCT, MPV and P-LCR were 274, 0.26, 10.08, and 24.8 (AUC: 0.661, 0.643, 0.593, 0.562), and PCT had preferable sensibility and specificity (50.84% and 70.42%) in predicting the presence of gynecological tumors. According to survival analysis, increased PLT (≥274 × 10 /L) and PCT (≥0.26), and induced MPV (<10.08 fL) and P-LCR (<24.8%) were associated with shorter overall survival.
Platelet count, PCT, MPV, and P-LCR can be used as preferable auxiliary parameters for predicting the presence of gynecological tumors. Increased PLT and PCT, or decreased MPV and P-LCR indicated a heavier tumor burden and shorter overall survival.
血小板在肿瘤细胞生长、转移和血管生成中发挥作用，本研究旨在评估血小板参数在妇科肿瘤患者中的诊断和预后价值。
共纳入 1062 名女性。采用非参数检验分析不同类别之间血小板参数（血小板计数[PLT]、血小板压积[PCT]、平均血小板体积[MPV]、血小板大细胞比率[P-LCR]和血小板分布宽度[PDW]）的差异。采用受试者工作特征分析计算最佳截断值。采用 Kaplan-Meier 法和对数秩检验进行单因素分析。
与对照组相比，恶性和良性妇科肿瘤组的血小板计数和血小板压积明显升高，MPV 和 P-LCR 明显降低（P<.001）；PDW 无显著差异。不同肿瘤部位和病理类型之间的 PLT、PCT、MPV、P-LCR 和 PDW 无显著差异。PLT、PCT、MPV 和 P-LCR 的最佳截断值分别为 274、0.26、10.08 和 24.8（AUC：0.661、0.643、0.593、0.562），PCT 在预测妇科肿瘤的存在方面具有更好的敏感性和特异性（50.84%和 70.42%）。根据生存分析，升高的 PLT（≥274×10 /L）和 PCT（≥0.26），以及诱导的 MPV（<10.08 fL）和 P-LCR（<24.8%）与总生存期缩短相关。
血小板计数、PCT、MPV 和 P-LCR 可作为预测妇科肿瘤存在的较好辅助参数。升高的 PLT 和 PCT，或降低的 MPV 和 P-LCR 表明肿瘤负荷较重，总生存期较短。
