Department of Cancer Surgery, VMMC and Safdarjung Hospital, New Delhi, India.
J Cancer Res Ther. 2022 Jul-Sep;18(4):1174-1176. doi: 10.4103/jcrt.JCRT_617_19.
Marjolin is an aggressive malignancy, which shows initial local aggression, followed by the rapid regional and distant dissemination during the latter part of its growth. Metastasis to the uveal tract, although infrequent, is usually secondary to the malignancies of the breast and lung. Marjolin's ulcer metastasizing to choroid is quite rare and unheard of. We intend to report one such case here. Here, we present a case report of a 55-year-old male, who developed Marjolin's ulcer over a previously injured left lower limb. He developed recurrence and re-recurrences requiring multiple surgeries, radiation, and chemotherapy cycles. He eventually developed disseminated systemic metastases. Over the course of his disease, he reported eye symptoms of pain, blurring of vision, and field defect in the left eye. On further evaluation with imaging and fundoscopy, a metastatic deposit was identified in the choroid of the left eye. Metastasis to the uveal tract is an unusual unreported event in the disease progression of Marjolin's ulcer. The treatment is usually palliative. It heralds the terminal stage of the disease, with inevitable death.
恶性黑色素瘤是一种侵袭性恶性肿瘤,其在生长后期表现出初始局部侵袭,随后迅速发生区域和远处播散。尽管转移到葡萄膜的情况并不常见,但通常是继发于乳腺和肺部的恶性肿瘤。恶性黑色素瘤溃疡转移到脉络膜非常罕见,闻所未闻。我们在此报告一例这样的病例。在这里,我们报告了一例 55 岁男性的病例,他在左下肢先前受伤的部位发生了恶性黑色素瘤溃疡。他经历了复发和再复发,需要多次手术、放疗和化疗周期。他最终出现了全身性播散转移。在疾病过程中,他报告左眼出现疼痛、视力模糊和视野缺损等眼部症状。进一步的影像学和眼底检查发现左眼脉络膜有转移灶。恶性黑色素瘤溃疡的疾病进展中,转移到葡萄膜是一种罕见且未报道的事件。治疗通常是姑息性的。它预示着疾病的终末期,不可避免地导致死亡。