Department of Pharmacodynamics, Medical University of Łódź, Muszyńskiego 1, 90-151 Łódź, Poland.
Department of Pharmacodynamics, Medical University of Łódź, Muszyńskiego 1, 90-151 Łódź, Poland.
Epilepsy Behav. 2022 Nov;136:108917. doi: 10.1016/j.yebeh.2022.108917. Epub 2022 Sep 20.
One of the newest antiseizure medication is levetiracetam (LEV). It might be effective in various indications, not only related to convulsions. Central nervous system disorders are common during anticonvulsant therapy. The aim of this study was to assess the effect of LEV on various types of memory and anxiety in rats.
Adult male Wistar rats (n = 58) were given LV p.o. as a single (100 mg/kg or 500 mg/kg) or repeated doses (300 mg/kg). The effect of the drug on memory was assessed in the Morris water maze (MWM) (spatial memory), the passive avoidance (PA) (emotional memory) and the novel object recognition (NOR) (recognition memory). The anxiety was evaluated in the elevated plus maze (EPM).
LEV administered as repeated doses disturbed the long-term recognition memory in NOR and locomotor activity in EPM. A single dose affected emotional memory in PA. LEV did not alter spatial memory in MWM.
LEV may cause memory and locomotor disturbances, but some of these adverse effects seem to be temporary and limited to the effect of acute dose.
左乙拉西坦（LEV）是最新的抗癫痫药物之一。它可能对各种适应症有效，不仅与抽搐有关。中枢神经系统疾病在抗癫痫治疗中很常见。本研究旨在评估 LEV 对大鼠各种类型记忆和焦虑的影响。
成年雄性 Wistar 大鼠（n=58）口服给予 LEV，单次（100mg/kg 或 500mg/kg）或重复剂量（300mg/kg）。在 Morris 水迷宫（MWM）（空间记忆）、被动回避（PA）（情绪记忆）和新物体识别（NOR）（识别记忆）中评估药物对记忆的影响。焦虑在高架十字迷宫（EPM）中进行评估。
LEV 重复给药会干扰 NOR 中的长期识别记忆和 EPM 中的运动活动。单次剂量会影响 PA 中的情绪记忆。LEV 未改变 MWM 中的空间记忆。
LEV 可能导致记忆和运动障碍，但其中一些不良反应似乎是暂时的，仅限于急性剂量的影响。
