Heinemeyer D, Bay W
Pflugers Arch. 1987 Jun;409(1-2):142-4. doi: 10.1007/BF00584762.
In ventricular trabeculae from guinea pig and cat heart superfused with a modified Tyrode's solution (pHo = 7.4) containing either 137 mM or 103 mM Clo-, intracellular pH (pHi) was measured with H+-sensitive double-barreled microelectrodes. In quiescent preparations pHi was 7.26 +/- 0.017 when Clo- was 137 mM, and 7.38 +/- 0.02 in 103 mM chloride. In 103 mM Clo- containing saline stimulation of the preparation produced no acidification but in 137 mM Clo- acidification occurred. The acidification was completely reversible when chloride was reduced again. When HCO3-/Cl- exchange was blocked by 0.5 mM SITS, pHi was lowered similar to the effect of increasing extracellular chloride concentration. It was concluded that when Clo- is raised, the HCO3-/Cl- exchanger operates as a Cl-/Cl- exchanger.
在豚鼠和猫心脏的心室小梁中，用含有137 mM或103 mM Cl⁻的改良台氏液（pHo = 7.4）进行 superfused，用对H⁺敏感的双管微电极测量细胞内pH（pHi）。在静态制剂中，当Cl⁻为137 mM时，pHi为7.26±0.017，在103 mM氯化物中为7.38±0.02。在含有103 mM Cl⁻的盐溶液中刺激制剂不会产生酸化，但在137 mM Cl⁻中会发生酸化。当氯化物再次降低时，酸化是完全可逆的。当0.5 mM SITS阻断HCO₃⁻/Cl⁻交换时，pHi降低，类似于增加细胞外氯化物浓度的效果。得出的结论是，当Cl⁻升高时，HCO₃⁻/Cl⁻交换器作为Cl⁻/Cl⁻交换器起作用。 （注：“superfused”这个词可能有误，推测是“superfused”，若有误请根据正确词汇调整翻译）
