Department of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Methods Mol Biol. 2023;2578:1-15. doi: 10.1007/978-1-0716-2732-7_1.
The diversity of the antigen-specific humoral immune response reflects the interaction of the immune system with pathogens and autoantigens. Peptide microarray analysis opens up new perspectives for the use of antibodies as diagnostic biomarkers and provides unique access to a more differentiated view on humoral responses to disease. This review focuses on the latest applications of peptide microarrays for the serologic medical diagnosis of autoimmunity, infectious diseases (including COVID-19), and cancer.
抗原特异性体液免疫反应的多样性反映了免疫系统与病原体和自身抗原的相互作用。肽微阵列分析为抗体作为诊断生物标志物的应用开辟了新的视角，并为更深入地了解疾病的体液反应提供了独特的途径。本文重点介绍了肽微阵列在自身免疫、传染病（包括 COVID-19）和癌症的血清学诊断中的最新应用。
