Xu Baojun, Li Wei, Lu Chunfeng, Wang Yanying, Li Chunya, Sun Dong
Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education & Hubei Key Laboratory of Catalysis and Materials Science & Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, South-Central Minzu University, Wuhan, 430074, China.
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Talanta. 2023 Feb 1;253:123910. doi: 10.1016/j.talanta.2022.123910. Epub 2022 Sep 8.
SnS nanorods with near-infrared photoelectric conversion characteristics were successfully synthesized through a simple hydrothermal method. Gold nanoparticles were self-assembled onto SnS nanorods surface to form SnS/AuNPs nanocomposites. The integration of AuNP can significantly improve the photocurrent response of SnS nanorods under being illuminated with 808 nm near-infrared light. A near-infrared photoelectrochemical immunosensing platform based on SNS/AuNPs nanocomposites was constructed for sensing gastric cancer tumor marker CA72-4. Experimental conditions were optimized to improve the immunosensing performances for CA72-4 determination. As CA72-4 concentration varied from 0.01 to 50 U mL, the photocurrent variation between the immunosensor before and after reacting with CA72-4 was linearly related to the logarithm of its concentration. The detection limit was calculated to be 0.008 U mL. The practicability of the immunosensor was demonstrated by determining CA72-4 in human serum samples.
