Ji Zengkai, Li Yao, He Shuijian, Ju Jian, Chen Yongfeng
College of Materials Science and Engineering, Nanjing Forestry University, Nanjing, 210037, China.
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001, China.
Mater Today Bio. 2025 Jul 1;33:102033. doi: 10.1016/j.mtbio.2025.102033. eCollection 2025 Aug.
Gastric cancer is one of the malignant tumors with a high global incidence and is one of the major public health challenges worldwide. The early diagnosis of gastric cancer has the potential to significantly enhance patient survival rates. Electrochemical biosensors possess the capability to detect biomarkers at low concentrations in whole blood samples, which has sparked considerable interest in their potential clinical applications. This review provides an overview of the role of structural diversity of low dimensional nanomaterials on the sensitivity and specificity approach of electrochemical biosensors. Furthermore, we highlight recent advancements in the development of electrochemical sensors for the detection of various gastric cancer biomarkers in blood samples. This review elucidates the design principles and performance metrics of these sensors, including their sensitivity and specificity. Finally, we address the issues currently encountered by electrochemical biosensors in the detection of gastric cancer and discusses the barriers to their clinical application, and propose potential solutions to these challenges.
胃癌是全球发病率较高的恶性肿瘤之一，也是全球主要的公共卫生挑战之一。胃癌的早期诊断有可能显著提高患者的生存率。电化学生物传感器能够在全血样本中检测低浓度的生物标志物，这引发了人们对其潜在临床应用的极大兴趣。本综述概述了低维纳米材料的结构多样性对电化学生物传感器灵敏度和特异性方法的作用。此外，我们重点介绍了用于检测血样中各种胃癌生物标志物的电化学传感器开发的最新进展。本综述阐明了这些传感器的设计原理和性能指标，包括它们的灵敏度和特异性。最后，我们讨论了电化学生物传感器在胃癌检测中目前遇到的问题，探讨了其临床应用的障碍，并提出了应对这些挑战的潜在解决方案。
