Fegeler K J
Fortschr Med. 1978 Nov 9;96(42):2169-72.
In the presence of predisposing factors which are considered as a local or general impairment of the host's defence mechanisms, the opportunistically pathogenic character of Candida albicans transforms into a parasitic one thus favoring the development of candidosis. The clinically reporting part of the paper deals with the predisposing factors and clinical features of candidosis. In animal experiments, we attempted to find out to what extent and whether exclusively the cellular immune system protects the host from Candida albicans infection. Our findings suggest that the cell-mediated immunity and phagocytosis are of fundamental importance in overcoming a candidosis and in resistance to Candida albicans. The humoral immune system plays a minor role, which may be limited to the stimulation of macrophages.
在存在被视为宿主防御机制局部或整体损害的易感因素时，白色念珠菌的机会致病性特征转变为寄生性特征，从而有利于念珠菌病的发展。本文的临床报告部分论述了念珠菌病的易感因素和临床特征。在动物实验中，我们试图弄清楚细胞免疫系统在多大程度上以及是否唯一地保护宿主免受白色念珠菌感染。我们的研究结果表明，细胞介导的免疫和吞噬作用对于克服念珠菌病以及抵抗白色念珠菌至关重要。体液免疫系统起次要作用，这可能仅限于对巨噬细胞的刺激。
