Health and Systems for Health Unit, African Population and Health Research Center (APHRC), Nairobi, Kenya; Lown Scholars Program, Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA; School of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, Tianjin 300072, China.
School of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, Tianjin 300072, China.
Hipertens Riesgo Vasc. 2023 Jan-Mar;40(1):5-15. doi: 10.1016/j.hipert.2022.08.001. Epub 2022 Sep 21.
Carotid intima media thickness (CIMT) is used as a marker of subclinical and asymptomatic atherosclerotic vascular disease. Increased CIMT is associated with future cerebrovascular and cardiovascular events. There is limited data on the profile and correlates of CIMT in Africa. The aim of this study was to describe the profile and correlates of CIMT in apparently normal younger-age adults in an urban setting in Kenya.
This study used population-based data collected from 2003 adults between the ages of 40 and 60 years in two slums of Nairobi as part of a genetic study. CIMT was measured using LOGIQ e (GE Healthcare, CT, USA) ultrasound on both left and right carotid arteries, whereby maximum, mean, and minimum values were recorded. Age- and sex-specific CIMT measurements were calculated and their association with basic sociodemographic, behavioral and body composition indicators were investigated.
The median (IQR) CIMT were 0.58 (0.51, 0.66) and 0.59 (0.53, 0.66) in men and women, respectively. About 16% of the study population had CIMT greater than 0.7mm, the cut off for higher CIMT. Nearly 60% had CIMT values ≥75th percentile. Age, current use of alcohol, systolic blood pressure, subcutaneous fat thickness, pulse rate and pulse pressure were found to be the main predictors of CIMT in our study population.
This study provided population-based reference values and predictors for CIMT for an adult population living in urban poor settings in Kenya. Future studies need to consider biochemical and genetic predictors of CIMT in this population.
颈动脉内膜中层厚度（CIMT）可作为亚临床和无症状动脉粥样硬化性血管疾病的标志物。CIMT 增加与未来的脑血管和心血管事件相关。非洲关于 CIMT 特征和相关因素的数据有限。本研究旨在描述肯尼亚城市贫困地区年龄在 40 至 60 岁之间的普通年轻成年人的 CIMT 特征和相关因素。
本研究使用了 2003 名年龄在 40 至 60 岁之间的成年人的基于人群的数据，这些人来自内罗毕的两个贫民窟，是一项遗传研究的一部分。使用 LOGIQ e（GE Healthcare，CT，USA）超声在左右颈动脉上测量 CIMT，记录最大、平均和最小值。计算了年龄和性别特异性的 CIMT 测量值，并研究了它们与基本社会人口统计学、行为和身体成分指标的相关性。
男性和女性的中位数（IQR）CIMT 分别为 0.58（0.51，0.66）和 0.59（0.53，0.66）。约 16%的研究人群 CIMT 大于 0.7mm，这是 CIMT 较高的切点。近 60%的人的 CIMT 值≥75 百分位数。在我们的研究人群中，年龄、当前饮酒、收缩压、皮下脂肪厚度、脉搏率和脉压被发现是 CIMT 的主要预测因素。
本研究为肯尼亚城市贫困地区的成年人群提供了基于人群的 CIMT 参考值和预测因素。未来的研究需要考虑该人群中 CIMT 的生化和遗传预测因素。
