Midtbø K, Hals O
Pharmacol Toxicol. 1987 May;60(5):330-2. doi: 10.1111/j.1600-0773.1987.tb01520.x.
The pressor effects of a single infusion of calcium gluconate (1375 mg) were measured in 20 patients, aged 31-63 years, with mild and moderate essential hypertension, being on long-term treatment with the slow calcium channel blocker verapamil. The calcium load induced a significant (P less than 0.001) increase in mean serum ionized calcium (from 1.24 +/- 0.01 to 1.40 +/- 0.2 mmol/l). This did not alter mean blood pressure or mean heart rate, although the individual patients responded differently to the mild hypercalcaemia; a significant fall in blood pressure being observed in a few patients. These results demonstrate the unpredictable effects of an increase in extracellular calcium on vascular smooth muscle cells and suggest that an intravenous bolus of 1375 mg calcium gluconate is not effective in counteracting the hypotensive action of verapamil.
对20例年龄在31至63岁之间、患有轻度和中度原发性高血压且长期服用慢钙通道阻滞剂维拉帕米的患者，测量了单次输注葡萄糖酸钙（1375毫克）后的升压作用。钙负荷使平均血清离子钙显著升高（P<0.001）（从1.24±0.01毫摩尔/升升至1.40±0.2毫摩尔/升）。这并未改变平均血压或平均心率，尽管个体患者对轻度高钙血症的反应有所不同；少数患者出现了血压显著下降。这些结果表明细胞外钙增加对血管平滑肌细胞的影响不可预测，并提示静脉推注1375毫克葡萄糖酸钙不能有效对抗维拉帕米的降压作用。
