Midtbø K, Hals O
Medical Department, Ullevaal Hospital, Oslo, Norway.
Angiology. 1987 Nov;38(11):841-6. doi: 10.1177/000331978703801106.
In 20 patients with mild to moderate essential hypertension, serum ionized calcium was determined before and after four weeks of treatment with 240 mg verapamil sustained release bid. Pretreatment systolic blood pressure was inversely correlated to serum ionized calcium (r = -0.44, p = 0.05). Mean blood pressure was significantly (p less than 0.001) reduced (from 161/100 to 145/88 mm Hg), but mean serum ionized calcium did not change during treatment (from 1.23 to 1.24 mmol/L). A significant inverse correlation (r = -0.56, p = 0.01) was found between pretreatment serum ionized calcium and reduction in systolic blood pressure during verapamil treatment. Thus serum ionized calcium in untreated essential hypertensive patients may predict the blood pressure response to the slow calcium channel blocker verapamil.
对20例轻至中度原发性高血压患者，在给予240mg维拉帕米缓释片每日两次治疗四周前后测定血清离子钙。治疗前收缩压与血清离子钙呈负相关（r = -0.44，p = 0.05）。平均血压显著降低（p < 0.001）（从161/100降至145/88 mmHg），但治疗期间平均血清离子钙未发生变化（从1.23 mmol/L至1.24 mmol/L）。治疗前血清离子钙与维拉帕米治疗期间收缩压降低之间存在显著负相关（r = -0.56，p = 0.01）。因此，未经治疗的原发性高血压患者的血清离子钙可能预测对慢钙通道阻滞剂维拉帕米的血压反应。
