de Beaurepaire R, Freed W J
Pharmacol Biochem Behav. 1987 May;27(1):177-82. doi: 10.1016/0091-3057(87)90493-x.
The primary physiological function of calcitonin, a peptide hormone secreted by the thyroid gland, is to modulate plasma calcium concentrations. Calcitonin also has several effects on the central nervous system including an inhibition of feeding behavior. In the present study synthetic salmon calcitonin (15 ng in 0.3 microliter) was found to produce a marked suppression of eating when infused in several hypothalamic areas. The greatest inhibition was produced by infusions into the paraventricular nucleus of the hypothalamus, the perifornical area and several areas on the floor of the hypothalamus. A less marked inhibition of eating was produced by infusions in the nucleus accumbens. Infusions in the olfactory tubercule, the ventrolateral hypothalamus, the medial forebrain bundle and the posterior nucleus of the hypothalamus had no effect. It is concluded that the anorectic effects of calcitonin on the central nervous system are mediated by several hypothalamic and extrahypothalamic sites.
降钙素是一种由甲状腺分泌的肽类激素，其主要生理功能是调节血浆钙浓度。降钙素对中枢神经系统也有多种作用，包括抑制进食行为。在本研究中，发现合成鲑鱼降钙素（0.3微升中含15纳克）注入几个下丘脑区域时会显著抑制进食。注入下丘脑室旁核、穹窿周区和下丘脑底部的几个区域时产生的抑制作用最大。注入伏隔核时对进食的抑制作用较小。注入嗅结节、下丘脑腹外侧、内侧前脑束和下丘脑后核则没有效果。得出的结论是，降钙素对中枢神经系统的食欲抑制作用是由几个下丘脑和下丘脑外部位介导的。
