McCabe J T, Bitran D, Leibowitz S F
Pharmacol Biochem Behav. 1986 Apr;24(4):1047-56. doi: 10.1016/0091-3057(86)90454-5.
The present study examined the hypotheses that the midlateral perifornical region of the hypothalamus (PFH), at the level of the ventromedial nucleus, plays a crucial role in amphetamine (AMPH)-induced anorexia and that mediating fibers ascending to this brain region follow a midlateral course through the caudal hypothalamus. Electrolytic lesions that destroyed the PFH region attenuated the feeding suppression induced by intraperitoneal administration of AMPH. Lesions placed anterior, dorsal, or medial to this region, in contrast, did not decrease AMPH's effect. The medially-placed paraventricular nucleus lesion, in fact, enhanced drug response. Midlateral coronal wire-knife cuts in the caudal hypothalamus also attenuated AMPH anorexia. The crucial midlateral caudal hypothalamic cut also disrupted anorexia induced by direct injection of AMPH into the PFH area. The results obtained from the lesion data support the hypothesis that the PFH region is essential to AMPH's suppressive effect upon feeding, and the KC data suggest that crucial catecholamine fibers mediating this drug response ascend specifically through the midlateral portion of the hypothalamus.
下丘脑腹内侧核水平的下丘脑外侧穹窿周区（PFH）在苯丙胺（AMPH）诱导的厌食中起关键作用，且上行至该脑区的介导纤维沿下丘脑尾部的外侧中间路径走行。破坏PFH区的电解损伤减弱了腹腔注射AMPH所诱导的进食抑制。相比之下，位于该区域前方、背侧或内侧的损伤并未降低AMPH的作用。实际上，位于内侧的室旁核损伤增强了药物反应。下丘脑尾部的外侧中间冠状线刀切割也减弱了AMPH厌食。关键的下丘脑尾部外侧中间切割也破坏了将AMPH直接注射到PFH区所诱导的厌食。从损伤数据获得的结果支持以下假设：PFH区对AMPH对进食的抑制作用至关重要，而KC数据表明，介导这种药物反应的关键儿茶酚胺纤维专门通过下丘脑的外侧中间部分上行。
