de Beaurepaire R, Freed W J
Pharmacol Biochem Behav. 1987 May;27(1):183-6. doi: 10.1016/0091-3057(87)90494-1.
Calcitonin receptors are found in the brain, and intracerebral infusions of calcitonin can produce behavioral effects. Among these behavioral effects are decreases in food intake and decreases in amphetamine-induced locomotor activity. In previous experiments we found that decreases in food intake were induced by local administration of calcitonin into several hypothalamic sites and into the nucleus accumbens. In the present experiment calcitonin decreased locomotor activity when locally injected into the same sites where it decreases food intake. The areas where calcitonin is most effective in decreasing locomotor activity are located in the hypothalamus and nucleus accumbens, suggesting that these areas are the major sites of action of calcitonin in inhibiting amphetamine-induced locomotor activity.
降钙素受体存在于大脑中，脑内注射降钙素可产生行为效应。这些行为效应包括食物摄入量减少以及苯丙胺诱导的运动活动减少。在之前的实验中，我们发现通过向下丘脑的几个部位以及伏隔核局部注射降钙素可导致食物摄入量减少。在本实验中，当将降钙素局部注射到其减少食物摄入量的相同部位时，它会降低运动活动。降钙素在降低运动活动方面最有效的区域位于下丘脑和伏隔核，这表明这些区域是降钙素抑制苯丙胺诱导的运动活动的主要作用部位。
