Wang Zhiguang, Chen Ruipeng, Yang Shiping, Li Shuang, Gao Zhixian
Tianjin Key Laboratory of Risk Assessment and Control Technology for Environment and Food Safety, Institute of Environmental and Operational Medicine, Tianjin, 300050, China.
College of Chemistry and Materials Science, Shanghai Normal University, Shanghai, 200234, China.
Mater Today Bio. 2022 Sep 14;16:100430. doi: 10.1016/j.mtbio.2022.100430. eCollection 2022 Dec.
Deoxyribonucleic acid (DNA) hydrogels combine the properties of DNAs and hydrogels, and adding functionalized DNAs is key to the wide application of DNA hydrogels. In stimuli-responsive DNA hydrogels, the DNA transcends its application in genetics and bridges the gap between different fields. Specifically, the DNA acts as both an information carrier and a bridge in constructing DNA hydrogels. The programmability and biocompatibility of DNA hydrogel make it change macroscopically in response to a variety of stimuli. In order to meet the needs of different scenarios, DNA hydrogels were also designed into microcapsules, beads, membranes, microneedle patches, and other forms. In this study, the stimuli were classified into single biological and non-biological stimuli and composite stimuli. Stimuli-responsive DNA hydrogels from the past five years were summarized, including but not limited to their design and application, in particular logic gate pathways and signal amplification mechanisms. Stimuli-responsive DNA hydrogels have been applied to fields such as sensing, nanorobots, information carriers, controlled drug release, and disease treatment. Different potential applications and the developmental pro-spects of stimuli-responsive DNA hydrogels were discussed.
脱氧核糖核酸（DNA）水凝胶结合了DNA和水凝胶的特性，添加功能化DNA是DNA水凝胶广泛应用的关键。在刺激响应性DNA水凝胶中，DNA超越了其在遗传学中的应用，弥合了不同领域之间的差距。具体而言，DNA在构建DNA水凝胶时既作为信息载体又作为桥梁。DNA水凝胶的可编程性和生物相容性使其能够响应各种刺激而发生宏观变化。为了满足不同场景的需求，DNA水凝胶还被设计成微胶囊、珠子、膜、微针贴片等形式。在本研究中，刺激被分为单一生物和非生物刺激以及复合刺激。总结了过去五年的刺激响应性DNA水凝胶，包括但不限于它们的设计和应用，特别是逻辑门途径和信号放大机制。刺激响应性DNA水凝胶已应用于传感、纳米机器人、信息载体、控释药物和疾病治疗等领域。讨论了刺激响应性DNA水凝胶的不同潜在应用和发展前景。
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