Le Duc Thanh, Do Kien Hung, Do Tu Anh, Bui Hoai Thu Thi, Nguyen Chu Van
National Cancer Hospital, Hanoi, Vietnam.
Hanoi Medical University, Hanoi, Vietnam.
Case Rep Oncol. 2022 Aug 30;15(2):770-775. doi: 10.1159/000526337. eCollection 2022 May-Aug.
Squamous cell carcinoma admixed with large-cell neuroendocrine carcinoma of the uterine cervix is an extremely rare malignancy with a poor prognosis. We report a 50-year-old woman with mixed squamous cell carcinoma and large-cell neuroendocrine carcinoma of the uterine cervix with an individual history of early-stage breast cancer. She was diagnosed preoperatively with cervical cancer stage FIGO 1B2. However, during surgery, a lesion was found in Douglas's peritoneum. The histopathological result of surgical specimens was mixed squamous cell carcinoma and large-cell neuroendocrine carcinoma. Then, she received concurrent chemoradiotherapy. Currently, after 3 months of treatment, she has not developed recurrent lesions.
宫颈鳞状细胞癌合并大细胞神经内分泌癌是一种极其罕见的恶性肿瘤，预后较差。我们报告一名50岁女性，患有宫颈鳞状细胞癌和大细胞神经内分泌癌混合型，既往有早期乳腺癌病史。她术前被诊断为国际妇产科联盟（FIGO）1B2期宫颈癌。然而，手术过程中发现Douglas腹膜有一处病灶。手术标本的组织病理学结果为鳞状细胞癌和大细胞神经内分泌癌混合型。随后，她接受了同步放化疗。目前，经过3个月的治疗，她尚未出现复发病灶。
