Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Int J Gynecol Pathol. 2012 Sep;31(5):490-6. doi: 10.1097/PGP.0b013e31824735a5.
Endocervical adenocarcinomas (ECAs) uncommonly metastasize to the ovary; however, when they do they sometimes closely mimic a mucinous/endometrioid ovarian primary tumor. Here, 2 cases of mixed moderately differentiated ECA and high-grade cervical neuroendocrine carcinoma in which the ECA component metastasized to the ovary have been delineated and reported. In both cases, the primary tumor and the metastatic tumor were diffusely positive for p16 and high-risk human papillomavirus. Although similar to previously reported cases of adenocarcinoma in situ and invasive ECAs with ovarian involvement, none of the cases reported to date had concurrent neuroendocrine carcinoma with metastasis of the lower-grade component. In this respect, our cases are unique. The presence of lower uterine segment involvement in both cases and high-risk human papillomavirus positivity in the primary and metastatic tumors suggest a metastatic process, perhaps through transtubal spread, rather than independent primaries.
宫颈内膜腺癌（ECA）很少转移到卵巢；然而，当它们转移时，有时会非常类似于黏液性/子宫内膜样卵巢原发性肿瘤。在这里，描述并报告了 2 例混合性中分化 ECA 和高级别宫颈神经内分泌癌，其中 ECA 成分转移到卵巢。在这两种情况下，原发性肿瘤和转移性肿瘤均弥漫性表达 p16 和高危型人乳头瘤病毒。尽管与之前报道的伴有卵巢受累的原位腺癌和浸润性 ECA 类似，但迄今为止报告的病例均没有同时存在神经内分泌癌和低级别成分转移。在这方面，我们的病例是独特的。这两种情况下均存在子宫下段受累以及原发性和转移性肿瘤中高危型人乳头瘤病毒阳性，提示转移过程，可能通过输卵管播散，而不是独立的原发性肿瘤。
