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PALB2作为预测颅底脊索瘤患者预后的一个因素。

PALB2 as a factor to predict the prognosis of patients with skull base chordoma.

作者信息

Xiong Yujia, Li Mingxuan, Shen Yutao, Ma Tianshun, Bai Jiwei, Zhang Yazhuo

机构信息

Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

出版信息

Front Oncol. 2022 Sep 8;12:996892. doi: 10.3389/fonc.2022.996892. eCollection 2022.

DOI:10.3389/fonc.2022.996892
PMID:36158641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9493133/
Abstract

OBJECTIVE

This study aimed to study the role of PALB2 on the prognosis of skull base chordoma patients and the proliferation, migration, and invasion of chordoma cells.

METHODS

187 patients with primary skull base chordoma were involved in the study. Immunohistochemical analysis was used to measure the PALB2 protein expression. Kaplan-Meier analysis, univariate and multivariate Cox analysis were used to evaluate the impact of PALB2 on patient prognosis. A nomogram was established for predicting the progression free survival of chordoma patients. Cell counting kit-8, colony formation, transwell migration, and invasion assays were used to assess the proliferation, migration, and invasion of chordoma cells with PALB2 knockdown. TIMER 2.0 was used to explore the expression and prognostic role of PALB2 in cancers.

RESULTS

High PALB2 expression indicated an adverse prognosis in chordoma. A nomogram involved PALB2, degree of resection, pathology, and Al-mefty classification could accurately predict the progression free survival of chordoma patients. The proliferation, migration, and invasion of chordoma cells significantly decreased after PALB2 knockdown. Additionally, PALB2 showed high expression in various cancers and was associated with a poor prognosis.

CONCLUSION

In summary, our results reveal that high PALB2 expression indicates a poor prognosis of chordoma patients and promotes the malignant phenotypes of chordoma cells .

摘要

目的

本研究旨在探讨PALB2在颅底脊索瘤患者预后以及脊索瘤细胞增殖、迁移和侵袭中的作用。

方法

本研究纳入187例原发性颅底脊索瘤患者。采用免疫组织化学分析检测PALB2蛋白表达。采用Kaplan-Meier分析、单因素和多因素Cox分析评估PALB2对患者预后的影响。建立了预测脊索瘤患者无进展生存期的列线图。采用细胞计数试剂盒-8、集落形成、Transwell迁移和侵袭实验评估PALB2敲低后脊索瘤细胞的增殖、迁移和侵袭能力。使用TIMER 2.0探索PALB2在癌症中的表达及预后作用。

结果

PALB2高表达提示脊索瘤预后不良。包含PALB2、切除程度、病理及Al-Mefty分级的列线图可准确预测脊索瘤患者的无进展生存期。PALB2敲低后，脊索瘤细胞的增殖、迁移和侵袭能力显著降低。此外，PALB2在多种癌症中高表达，且与预后不良相关。

结论

总之，我们的结果表明，PALB2高表达提示脊索瘤患者预后不良，并促进脊索瘤细胞的恶性表型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d611/9493133/6ef8a63e9d11/fonc-12-996892-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d611/9493133/f4e8fbf0f187/fonc-12-996892-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d611/9493133/2c10e001a8ab/fonc-12-996892-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d611/9493133/b98024d6a491/fonc-12-996892-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d611/9493133/0088f02c2fa6/fonc-12-996892-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d611/9493133/53a033f0f908/fonc-12-996892-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d611/9493133/6ef8a63e9d11/fonc-12-996892-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d611/9493133/f4e8fbf0f187/fonc-12-996892-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d611/9493133/2c10e001a8ab/fonc-12-996892-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d611/9493133/b98024d6a491/fonc-12-996892-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d611/9493133/0088f02c2fa6/fonc-12-996892-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d611/9493133/53a033f0f908/fonc-12-996892-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d611/9493133/6ef8a63e9d11/fonc-12-996892-g006.jpg

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PALB2 Variants: Protein Domains and Cancer Susceptibility.PALB2 变异：蛋白结构域与癌症易感性。
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A nomogram to predict the progression-free survival of clival chordoma.
一种预测斜坡脊索瘤无进展生存期的列线图。
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Predictive Value of Transforming Growth Factor-α and Ki-67 for the Prognosis of Skull Base Chordoma.转化生长因子-α和 Ki-67 对颅底脊索瘤预后的预测价值。
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