Wales J K
Int J Obes. 1980;4(2):127-32.
Fenfluramine therapy 180 mg per day did not increase the rate of weight loss in obese patients either undergoing therapeutic starvation or receiving a 300 kcal diet; neither did the drug alter those biochemical changes associated with these dietary regimes. These results suggest that fenfluramine does not cause weight loss in the obese patient by a major metabolic action but by its effect on appetite. However, there were significant differences in the ratios of fenfluramine to norfenfluramine in the plasma and urine of patients on each dietary regimen.
每天180毫克的芬氟拉明疗法，对于正在接受治疗性饥饿或摄入300千卡饮食的肥胖患者，并没有提高其体重减轻的速率；该药物也没有改变与这些饮食方案相关的生化变化。这些结果表明，芬氟拉明并非通过主要的代谢作用导致肥胖患者体重减轻，而是通过其对食欲的影响。然而，接受每种饮食方案的患者血浆和尿液中芬氟拉明与去甲芬氟拉明的比例存在显著差异。
