抗真菌药物耐药性：进化、机制和影响。
Antifungal drug resistance: evolution, mechanisms and impact.
机构信息
Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1M1, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1M1, Canada.
出版信息
Curr Opin Microbiol. 2018 Oct;45:70-76. doi: 10.1016/j.mib.2018.02.005. Epub 2018 Mar 13.
Abstract
Microorganisms have a remarkable capacity to evolve resistance to antimicrobial agents, threatening the efficacy of the limited arsenal of antimicrobials and becoming a dire public health crisis. This is of particular concern for fungal pathogens, which cause devastating invasive infections with treatment options limited to only three major classes of antifungal drugs. The paucity of antifungals with clinical utility is in part due to close evolutionary relationships between these eukaryotic pathogens and their human hosts, which limits the unique targets to be exploited therapeutically. This review highlights the mechanisms by which fungal pathogens of humans evolve resistance to antifungal drugs, which provide crucial insights to enable development of novel therapeutic strategies to thwart drug resistance and combat fungal infectious disease.
摘要
微生物具有对抗生素产生耐药性的惊人能力，这威胁到有限的抗生素储备的疗效，成为一个严重的公共卫生危机。这对于真菌病原体尤其令人担忧，因为它们会导致破坏性的侵袭性感染，而治疗选择仅限于三种主要类别的抗真菌药物。具有临床应用价值的抗真菌药物的缺乏部分是由于这些真核病原体与其人类宿主之间密切的进化关系，这限制了可用于治疗的独特靶点。这篇综述强调了人类真菌感染病原体对抗真菌药物产生耐药性的机制，这些机制为开发新的治疗策略以阻止耐药性和对抗真菌感染性疾病提供了至关重要的见解。
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