母亲抑郁与新生儿结局的关联：基于全国代表性纵向研究调查的证据。
Association between maternal depression and neonatal outcomes: Evidence from a survey of nationally representative longitudinal studies.
机构信息
School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an, China.
Vanke School of Public Health, Tsinghua University, Beijing, China.
出版信息
Front Public Health. 2022 Sep 9;10:893518. doi: 10.3389/fpubh.2022.893518. eCollection 2022.
BACKGROUND AND AIMS
Maternal depression before and after delivery has dramatically increased in China. Therefore, this study aimed to examine the association between antepartum and postpartum depression and neonatal outcomes.
DESIGN
A population-based retrospective cohort study.
SETTING
China.
PARTICIPANTS
Data were obtained from China Family Panel Studies (CFPS). Different mother-child/infant samples were included in this study. Mother in CFPS2012 and CFPS2016 were linked with 1-2-year-old children in CFPS2014 and CFPS2018, respectively. Besides, and mothers in CFPS2012, CFPS2016, and CFPS2018 were linked with 0-1-year-old infants in CFPS2012, CFPS2016, and CFPS2018, respectively.
METHODS
Maternal depression was measured using the Center for Epidemiologic Studies Depression Scale. The neonatal outcomes included duration of gestational days, preterm birth, birth weight, birth weight z-score, weight, weight z-score, illness in the past month, and hospitalization in the past year. Propensity score matching was used to balance maternal, family, and infant/child characteristics between the maternal depression and non-maternal depression groups.
RESULTS
Multivariable regression analysis of matched samples estimated that antepartum depression was associated with a shorter duration of gestation by 3.99 days (95% confidence interval [CI] = -7.21, -0.78). The association between antepartum depression and preterm birth, birth weight and birth weight z-score were not statistically significant. Postpartum depression was associated with more episodes of illness in the last month by 0.23 times (95% CI = 0.11, 0.36) and a higher odd of hospitalization in the previous year (OR = 1.59, 95% CI = 1.15, 2.20). The association between postpartum depression and weight or the weight z-score was not significant.
CONCLUSION
Maternal depression appears to be associated with worse neonatal outcomes.
背景与目的
在中国，产妇产前和产后抑郁的发生率显著增加。因此，本研究旨在探讨产前和产后抑郁与新生儿结局的关系。
设计
基于人群的回顾性队列研究。
地点
中国。
参与者
数据来自中国家庭追踪调查（CFPS）。本研究纳入了不同的母婴/婴儿样本。CFPS2012 年的母亲与 CFPS2014 年和 CFPS2018 年 1-2 岁的儿童相关联，CFPS2016 年的母亲与 CFPS2018 年的儿童相关联。此外，CFPS2012 年、CFPS2016 年和 CFPS2018 年的母亲与 CFPS2012 年、CFPS2016 年和 CFPS2018 年的婴儿相关联。
方法
使用中心流行病学研究抑郁量表（CES-D）来测量产妇抑郁情况。新生儿结局包括妊娠天数、早产、出生体重、出生体重 z 评分、体重、体重 z 评分、过去 1 个月的疾病和过去 1 年的住院情况。采用倾向评分匹配法来平衡产妇抑郁组和非产妇抑郁组之间的产妇、家庭和婴儿/儿童特征。
结果
匹配样本的多变量回归分析估计，产前抑郁与妊娠天数减少 3.99 天相关（95%置信区间[CI]：-7.21，-0.78）。产前抑郁与早产、出生体重和出生体重 z 评分之间的关系无统计学意义。产后抑郁与过去 1 个月疾病发作次数增加 0.23 倍（95%CI：0.11，0.36）和过去 1 年住院的可能性增加（OR = 1.59，95%CI：1.15，2.20）相关。产后抑郁与体重或体重 z 评分之间的关系不显著。
结论
产妇抑郁似乎与新生儿结局较差有关。
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