Pereira Leudimar Aires, Reis Luizângela da Silva, Mendes Anderson Nogueira, Fernandes Hélio de Barros, Arcanjo Daniel Dias Rufino, Rodrigues Júnior Adalberto Fortes, Sousa Janete Martins, Barreto Humberto Medeiros, Santos Jailson de Araújo, Osajima Josy Anteveli, Silva Filho Edson C
Interdisciplinary Laboratory of Advanced Materials, Postgraduate Program in Materials Science, Federal University of Piauí, CEP: 64049-550, Teresina, Piauí, Brazil.
Laboratory of Biology, Department of Biology, Universidade Federal do Piauí, 64800-000, Floriano, Piauí, Brazil.
Evid Based Complement Alternat Med. 2022 Sep 16;2022:4743041. doi: 10.1155/2022/4743041. eCollection 2022.
Gastric ulcer is an injury that develops on the lining of the stomach due to an imbalance between aggressive and defensive agents. Chitosan derivatives demonstrate promising biological activities in accelerating the healing activity of gastric lesions. Thus, this study aimed at investigating the healing activity of gastric lesion, induced by acetic acid (80%), of the chitosan derivative with acetylacetone (Cac) modified with ethylenediamine (Cacen) or diethylenetriamine (Cacdien). The biological activity was determined based on cytotoxicity, antibacterial activity, and gastroprotective activities. The results showed no significant difference in the cytotoxicity, a better antibacterial activity against and , and a positive result on the healing of gastric lesions of the materials (Cac 18.4%, Cacen 55.2%, and Cacdien 68.1%) compared to pure chitosan (50.7%). Therefore, the results indicate that derivatives of chitosan are promising biomaterials for application in the control of lesions on the gastric mucosa.
胃溃疡是由于攻击因子和防御因子失衡而在胃黏膜上形成的损伤。壳聚糖衍生物在加速胃损伤愈合方面显示出有前景的生物活性。因此，本研究旨在探究用乙二胺（Cacen）或二亚乙基三胺（Cacdien）修饰的乙酰丙酮壳聚糖衍生物（Cac）对80%乙酸诱导的胃损伤的愈合活性。基于细胞毒性、抗菌活性和胃保护活性来测定生物活性。结果显示，与纯壳聚糖（50.7%）相比，材料（Cac 18.4%、Cacen 55.2%和Cacdien 68.1%）的细胞毒性无显著差异，对 和 具有更好的抗菌活性，且对胃损伤愈合有积极效果。因此，结果表明壳聚糖衍生物是用于控制胃黏膜损伤的有前景的生物材料。
