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通过定量吸入器口服吸入大麻二酚，以减轻由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）和污染物诱导的细胞因子产生。

Oral inhalation of cannabidiol delivered from a metered dose inhaler to alleviate cytokine production induced by SARS-CoV-2 and pollutants.

作者信息

Srichana Teerapol, Chunhachaichana Charisopon, Suedee Roongnapa, Sawatdee Somchai, Changsan Narumon

机构信息

Drug Delivery System Excellence Center, Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand.

Molecular Recognition Materials Research Unit, Drug Delivery System Excellence Center, Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University Hatyai, Songkhla, 90112, Thailand.

出版信息

J Drug Deliv Sci Technol. 2022 Oct;76:103805. doi: 10.1016/j.jddst.2022.103805. Epub 2022 Sep 17.

DOI:10.1016/j.jddst.2022.103805
PMID:36159727
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9482090/
Abstract

Cannabidiol (CBD) was formulated as a metered dose inhaler (CBD-MDI) and evaluated for its efficacy as an inhaled dosage form against inflammation caused by the SARS-CoV-2 virus, lipopolysaccharide (LPS) from , silica particles, nicotine, and coal tar. A CBD-MDI formulation was prepared with 50 mg of CBD in 10 mL for a CBD dose of 250 μg/puff. The formulation ingredients included CBD, absolute ethanol as a cosolvent, and HFA-134a as the propellant. High aerosol performance of CBD-MDI was obtained with mass median aerodynamic diameter of 1.25 ± 0.01 μm, geometric standard deviation of 1.75 ± 0.00, emitted dose of 244.7 ± 2.1 μg, and fine particle dose of 122.0 ± 1.6 μg. The cytotoxicity and anti-inflammatory effectiveness of CBD-MDI were performed in alveolar macrophage (NR8383) and co-culture of alveolar macrophage (NR8383) and human lung adenocarcinoma (A549) cell line. CBD delivered from an MDI was safe on respiratory cells and did not trigger an immune response in alveolar macrophages. CBD-MDI effectively reduced the generation of cytokines in immune cells treated with viral antigen S-RBD, bacterial antigen LPS, silica particles, and coal tar. The efficacy of CBD-MDI was comparable to budesonide. Furthermore, the findings demonstrated that the use of CBD-MDI was more effective in treatment rather than prevention when inflammation was induced by either a viral or bacterial stimulant.

摘要

大麻二酚（CBD）被制成定量吸入器（CBD-MDI），并评估其作为吸入剂型对由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒、脂多糖（LPS）、二氧化硅颗粒、尼古丁和煤焦油引起的炎症的疗效。制备了一种CBD-MDI制剂，10毫升中含有50毫克CBD，每喷剂量为250微克。制剂成分包括CBD、作为助溶剂的无水乙醇和作为推进剂的HFA-134a。CBD-MDI具有高气溶胶性能，质量中值空气动力学直径为1.25±0.01微米，几何标准偏差为1.75±0.00，喷出剂量为244.7±2.1微克，细颗粒剂量为122.0±1.6微克。在肺泡巨噬细胞（NR8383）以及肺泡巨噬细胞（NR8383）与人肺腺癌（A549）细胞系的共培养物中进行了CBD-MDI的细胞毒性和抗炎有效性研究。从MDI递送的CBD对呼吸道细胞安全，不会在肺泡巨噬细胞中引发免疫反应。CBD-MDI有效减少了用病毒抗原S-RBD、细菌抗原LPS、二氧化硅颗粒和煤焦油处理的免疫细胞中细胞因子的产生。CBD-MDI的疗效与布地奈德相当。此外，研究结果表明，当由病毒或细菌刺激物诱导炎症时，使用CBD-MDI治疗比预防更有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/1f13c9df658e/gr8_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/3f25fb2c42e2/ga1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/9b7f91f5ae1f/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/9fb4bc0ddf5f/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/d3f15d644e19/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/dbba8d106ae2/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/a7eed15f9dda/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/7e6f8a2f86be/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/3d38cfd35dbe/gr7_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/1f13c9df658e/gr8_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/3f25fb2c42e2/ga1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/9b7f91f5ae1f/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/9fb4bc0ddf5f/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/d3f15d644e19/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/dbba8d106ae2/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/a7eed15f9dda/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/7e6f8a2f86be/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/3d38cfd35dbe/gr7_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/9482090/1f13c9df658e/gr8_lrg.jpg

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