Wu Zhenyu, Liu Luying
First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
First Clinical Medical College of Gannan Medical University, Ganzhou, China.
Front Pharmacol. 2022 Sep 8;13:1016981. doi: 10.3389/fphar.2022.1016981. eCollection 2022.
Genistein, a natural isoflavone rich in soybean and leguminous plants, has been shown various biological effects, such as anti-inflammation, anti-oxidation, anti-cancer, and bone/cartilage protection. Due to the structural similarity to estrogen, genistein exhibits estrogen-like activity in protecting against osteoporosis and osteoarthritis. Furthermore, genistein has been considered as an inhibitor of tyrosine kinase, which has been found to be dysregulated in the pathological development of osteoporosis, osteoarthritis, and intervertebral disc degeneration (IDD). Many signaling pathways, such as MAPK, NF-κB, and NRF2/HO-1, are involved in the regulatory activity of genistein in protecting against bone and cartilage diseases. The potential molecular mechanisms of genistein in therapeutic management of bone and cartilage diseases have been investigated, but remain to be fully understood. In this article, we mainly discuss the current knowledge of genistein in protecting against bone and cartilage diseases, such as osteoporosis, osteoarthritis, rheumatoid arthritis (RA), and IDD.
染料木黄酮是一种富含于大豆和豆科植物中的天然异黄酮，已被证明具有多种生物学效应，如抗炎、抗氧化、抗癌以及保护骨骼/软骨等作用。由于其结构与雌激素相似，染料木黄酮在预防骨质疏松症和骨关节炎方面表现出类似雌激素的活性。此外，染料木黄酮被认为是一种酪氨酸激酶抑制剂，而酪氨酸激酶在骨质疏松症、骨关节炎和椎间盘退变（IDD）的病理发展过程中被发现存在失调现象。许多信号通路，如丝裂原活化蛋白激酶（MAPK）、核因子κB（NF-κB）和核因子E2相关因子2/血红素加氧酶-1（NRF2/HO-1），都参与了染料木黄酮对骨骼和软骨疾病的保护调节活性。虽然已经对染料木黄酮在治疗骨骼和软骨疾病方面的潜在分子机制进行了研究，但仍有待充分了解。在本文中，我们主要讨论目前关于染料木黄酮在预防骨骼和软骨疾病，如骨质疏松症、骨关节炎、类风湿性关节炎（RA）和IDD方面的知识。
