Center for Translational Medicine Research and Development, Shen Zhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen University Town, 1068 Xueyuan Avenue, Shenzhen, Guangdong 518055, China.
Clin Rheumatol. 2013 May;32(5):535-40. doi: 10.1007/s10067-012-2148-4. Epub 2013 Jan 10.
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that may affect many tissues and organs. Without treatment, inflammation leads to cartilage damage, bone erosions, joint destruction, and impaired movement. Because of the limited success of disease-modifying anti-rheumatic drugs, the exploration of new anti-rheumatic drugs with high efficacy and less toxicity is eagerly needed. Genistein, the major active compound from soybean, has received much attention due to its potential beneficial effects on some of the degenerative diseases. It has been found that genistein has anti-inflammatory, antiangiogenesis, antiproliferative, antioxidant, immunomodulatory, pain relief, and joint protection properties. Hence, significant advances have been made, both by in vitro and in vivo studies showing that genistein is a promising agent for RA treatment.
类风湿关节炎（RA）是一种慢性、全身性炎症性疾病，可能影响许多组织和器官。如果不进行治疗，炎症会导致软骨损伤、骨侵蚀、关节破坏和运动功能受损。由于疾病修饰抗风湿药物的疗效有限，因此迫切需要探索新的、疗效更高、毒性更低的抗风湿药物。大豆中的主要活性化合物染料木黄酮因其对一些退行性疾病的潜在有益作用而受到广泛关注。研究发现，染料木黄酮具有抗炎、抗血管生成、抗增殖、抗氧化、免疫调节、止痛和关节保护作用。因此，无论是体外研究还是体内研究都取得了重大进展，表明染料木黄酮是治疗 RA 的一种有前途的药物。
