Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA. Electronic address: https://twitter.com/JuanP_Angell.
Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA.
Curr Opin Neurobiol. 2022 Dec;77:102629. doi: 10.1016/j.conb.2022.102629. Epub 2022 Sep 23.
Programmed cell death (PCD) is an essential mechanism of antimicrobial defense. Recent work has revealed an unexpected diversity in the types of PCD elicited during infection, as well as defined unique roles for different PCD modalities in shaping the immune response. Here, we review recent work describing unique ways in which PCD signaling operates within the infected central nervous system (CNS). These studies reveal striking complexity in the regulation of PCD signaling by CNS cells, including both protective and pathological outcomes in the control of infection. Studies defining the specialized molecular mechanisms shaping PCD responses in the CNS promise to yield much needed new insights into the pathogenesis of neuroinvasive viral infection, informing future therapeutic development.
程序性细胞死亡（PCD）是抗菌防御的重要机制。最近的研究揭示了在感染过程中引发的 PCD 类型的意想不到的多样性，并确定了不同 PCD 方式在塑造免疫反应中的独特作用。在这里，我们回顾了最近描述 PCD 信号在感染的中枢神经系统（CNS）中运作的独特方式的工作。这些研究揭示了 CNS 细胞中 PCD 信号调节的惊人复杂性，包括感染控制中保护性和病理性结果。定义塑造 CNS 中 PCD 反应的特殊分子机制的研究有望为神经侵袭性病毒感染的发病机制提供急需的新见解，并为未来的治疗开发提供信息。
