School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
ACS Chem Neurosci. 2022 Jun 15;13(12):1697-1713. doi: 10.1021/acschemneuro.2c00172. Epub 2022 May 23.
Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder featured by memory loss and cognitive default. However, there has been no effective therapeutic approach to prevent the development of AD and the available therapies are only to alleviate some symptoms with limited efficacy and severe side effects. Necroptosis is a new kind of cell death, being regarded as a genetically programmed and regulated pattern of necrosis. Increasing evidence reveals that necroptosis is tightly related to the occurrence and development of AD. This review aims to summarize the potential role of necroptosis in AD progression and the therapeutic capacity of targeting necroptosis for AD patients.
阿尔茨海默病（AD）是一种不可逆的进行性神经退行性疾病，其特征是记忆丧失和认知功能障碍。然而，目前还没有有效的治疗方法来预防 AD 的发展，现有的治疗方法只能缓解一些症状，疗效有限，副作用严重。细胞坏死性凋亡是一种新的细胞死亡方式，被认为是一种基因编程和调控的坏死模式。越来越多的证据表明，细胞坏死性凋亡与 AD 的发生和发展密切相关。本综述旨在总结细胞坏死性凋亡在 AD 进展中的潜在作用，以及针对 AD 患者的细胞坏死性凋亡治疗的潜力。
