质子泵抑制剂在过敏中的作用：获益与风险。
Proton Pump Inhibitors in Allergy: Benefits and Risks.
机构信息
Beth Israel Lahey Health, Lahey Clinic, Burlington, Mass.
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, Pa.
出版信息
J Allergy Clin Immunol Pract. 2022 Dec;10(12):3117-3123. doi: 10.1016/j.jaip.2022.09.022. Epub 2022 Sep 23.
Abstract
Proton pump inhibitors (PPIs) are widely prescribed and are indicated for the treatment of several gastrointestinal disorders. Allergists may prescribe PPIs as a result of the coincidence of gastroesophageal reflux disease with asthma or rhinitis, or when gastroesophageal reflux disease presents as chronic cough. Furthermore, long-term, high-dose PPI therapy is a recommended option for managing eosinophilic esophagitis, resulting in histologic remission in approximately 40% of patients. Here, we discuss current recommendations for PPI use, its deescalation, and its side effect profile. We review evidence supporting the epidemiologic link between the use of acid-suppressant medication and the subsequent development of allergic disorders.
摘要
质子泵抑制剂 (PPIs) 被广泛开处方，用于治疗几种胃肠道疾病。过敏症专家可能会因为胃食管反流病与哮喘或鼻炎同时发生，或者当胃食管反流病表现为慢性咳嗽时开处方使用 PPIs。此外，长期、高剂量 PPI 治疗是管理嗜酸性食管炎的推荐选择，大约 40%的患者可实现组织学缓解。在这里，我们讨论了目前关于 PPI 使用、剂量下调及其副作用的建议。我们回顾了支持抑酸药物使用与随后发生过敏疾病之间的流行病学联系的证据。
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