Jusic Amela, Stellos Konstantinos, Ferreira Lino, Baker Andrew H, Devaux Yvan
Cardiovascular Research Unit, Department of Precision Health, Luxembourg Institute of Health, L-1445 Strassen, Luxembourg.
Department of Biology, Faculty of Natural Sciences and Mathematics, University of Tuzla, 75000 Tuzla, Bosnia and Herzegovina.
J Mol Cell Cardiol Plus. 2022 Sep;1:100013. doi: 10.1016/j.jmccpl.2022.100013. Epub 2022 Jul 28.
Although systemic inflammation and pulmonary complications increase the mortality rate in COVID-19, a broad spectrum of cardiovascular and neurological complications can also contribute to significant morbidity and mortality. The molecular mechanisms underlying cardiovascular and neurological complications during and after SARS-CoV-2 infection are incompletely understood. Recently reported perturbations of the epitranscriptome of COVID-19 patients indicate that mechanisms including those derived from RNA modifications and non-coding RNAs may play a contributing role in the pathogenesis of COVID-19. In this review paper, we gathered recently published studies investigating (epi)transcriptomic fluctuations upon SARS-CoV-2 infection, focusing on the brain-heart axis since neurological and cardiovascular events and their sequelae are of utmost prevalence and importance in this disease.
尽管全身炎症和肺部并发症会增加COVID-19的死亡率，但广泛的心血管和神经并发症也会导致显著的发病率和死亡率。SARS-CoV-2感染期间及之后心血管和神经并发症的分子机制尚未完全明确。最近报道的COVID-19患者表观转录组的扰动表明，包括那些源自RNA修饰和非编码RNA的机制可能在COVID-19的发病机制中起作用。在这篇综述文章中，我们收集了最近发表的研究，这些研究调查了SARS-CoV-2感染后的（表观）转录组波动，由于神经和心血管事件及其后遗症在该疾病中最为常见且最为重要，因此重点关注脑-心轴。
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