Schmajuk N A
Schizophr Bull. 1987;13(2):317-27. doi: 10.1093/schbul/13.2.317.
Animals with hippocampal lesions are evaluated as models for schizophrenia according to the criteria of McKinney and Bunney (1969). They seem to comply adequately with the following requirements: similarity of inducing conditions; similarity of behavioral states; similarity of underlying neurobiological mechanisms; and reversibility by usual pharmacological treatment. The model seems adequate to reproduce several symptoms of the disorder, offering a good experimental tool for the analysis of its inducing conditions, affected neurobiological mechanisms, and clinical treatment.
根据麦金尼和邦尼（1969年）的标准，对海马体受损的动物进行评估，将其作为精神分裂症的模型。它们似乎充分符合以下要求：诱发条件的相似性；行为状态的相似性；潜在神经生物学机制的相似性；以及通过常规药物治疗的可逆性。该模型似乎足以重现该疾病的几种症状，为分析其诱发条件、受影响的神经生物学机制和临床治疗提供了一个良好的实验工具。
