Port R L, Sample J A, Seybold K S
Department of Psychology, Slippery Rock University, PA 16057.
Brain Res Bull. 1991 Jun;26(6):993-6. doi: 10.1016/0361-9230(91)90268-o.
A putative biological substrate of schizophrenia involves cellular pathology within the hippocampus. While hippocampal dysfunction is associated with impaired learning and memory, schizophrenics have been observed to acquire simple conditioned reflexes at rates superior to controls. The present study evaluates the acquisition of shuttlebox avoidance responses in animals with partial damage to hippocampus. Intraventricular microinjections of kainic acid (0.5 or 1.5 nM) were utilized to partially destroy the pyramidal cell population. Animals in the high dosage group acquired the response at rates superior to controls; the low dosage group performed at an intermediate level. Consequently, partial loss of pyramidal neurons may be sufficient to significantly alter simple acquisition. Results are discussed in reference to the "embryological hypothesis" of schizophrenia and mechanisms for induction of schizophrenic behavior in intractable seizure disorders are considered.
精神分裂症一种假定的生物学基础涉及海马体中的细胞病理学。虽然海马体功能障碍与学习和记忆受损有关，但已观察到精神分裂症患者获得简单条件反射的速度优于对照组。本研究评估了海马体部分受损动物对穿梭箱回避反应的习得情况。通过脑室内微量注射海藻酸（0.5或1.5纳摩尔）来部分破坏锥体细胞群。高剂量组动物获得反应的速度优于对照组；低剂量组表现处于中等水平。因此，锥体细胞的部分缺失可能足以显著改变简单习得过程。结合精神分裂症的“胚胎学假说”对结果进行了讨论，并考虑了难治性癫痫障碍中诱发精神分裂症行为的机制。
