Su Xin, Cai Xueli, Pan Yuesong, Sun Jingping, Jing Jing, Wang Mengxing, Meng Xia, Wang Yongjun, Wei Tiemin, He Yan
Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
Eur J Prev Cardiol. 2022 Dec 21;29(18):2349-2358. doi: 10.1093/eurjpc/zwac223.
High level of apolipoprotein B (Apo B) is associated with incident subclinical atherosclerosis. The present study evaluated the associations between discordant Apo B with low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and coronary atherosclerotic burden.
This study enrolled 3043 participants aged 50-75 years from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study that was conducted in the community in Lishui City, China. Discordant Apo B with LDL-C and non-HDL-C were defined by residuals and medians. Coronary atherosclerotic burden was evaluated by segment involvement score (SIS) and segment stenosis score (SSS) which were determined by computed tomography angiography. We performed discordance analyses examining associations of discordant Apo B with LDL-C or non-HDL-C with the coronary atherosclerotic burden. The mean age of participants was 61.2 ± 6.7 years, 53.6% were females. Participants with discordant high Apo B relative to non-HDL-C were at higher odds of plaques [odds ratio (OR), 1.30; 95% confidence interval (CI), 1.08-1.57], SIS [common odds ratio (cOR), 1.35; 95% CI, 1.14-1.60], and SSS (cOR, 1.40; 95% CI, 1.18-1.67) compared with concordant group. However, discordantly low Apo B with non-HDL-C was associated with decreased odds of the coronary atherosclerotic plaques and its burden. Similar results were shown for discordant analyses for Apo B with LDL-C.
Discordantly high Apo B with LDL-C and non-HDL-C were associated with an increased odds of the coronary atherosclerotic plaques and its burden. These findings highlighted the importance of Apo B for primary prevention of coronary atherosclerosis.
载脂蛋白B（Apo B）水平升高与亚临床动脉粥样硬化的发生相关。本研究评估了Apo B与低密度脂蛋白胆固醇（LDL-C）、非高密度脂蛋白胆固醇（非HDL-C）不一致以及冠状动脉粥样硬化负荷之间的关联。
本研究纳入了来自中国丽水市社区进行的认知障碍和血管事件的多血管评估（PRECISE）研究中的3043名年龄在50 - 75岁的参与者。Apo B与LDL-C和非HDL-C的不一致通过残差和中位数来定义。冠状动脉粥样硬化负荷通过计算机断层血管造影确定的节段累及评分（SIS）和节段狭窄评分（SSS）进行评估。我们进行了不一致性分析，检查Apo B与LDL-C或非HDL-C不一致与冠状动脉粥样硬化负荷之间的关联。参与者的平均年龄为61.2±6.7岁，53.6%为女性。与一致组相比，相对于非HDL-C而言Apo B不一致性高的参与者出现斑块的几率更高[比值比（OR），1.30；95%置信区间（CI），1.08 - 1.57]、SIS[共同比值比（cOR），1.35；95% CI，1.14 - 1.60]和SSS（cOR，1.40；95% CI，1.18 - 1.67）。然而，Apo B与非HDL-C不一致性低与冠状动脉粥样硬化斑块及其负荷几率降低相关。Apo B与LDL-C的不一致性分析也显示了类似结果。
Apo B与LDL-C和非HDL-C不一致性高与冠状动脉粥样硬化斑块及其负荷几率增加相关。这些发现突出了Apo B在冠状动脉粥样硬化一级预防中的重要性。
