胆固醇和脂蛋白参数与颈动脉斑块特征的关系：动脉粥样硬化风险社区（ARIC）颈动脉 MRI 研究。
Relation of cholesterol and lipoprotein parameters with carotid artery plaque characteristics: the Atherosclerosis Risk in Communities (ARIC) carotid MRI study.
机构信息
Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, United States.
出版信息
Atherosclerosis. 2011 Dec;219(2):596-602. doi: 10.1016/j.atherosclerosis.2011.08.001. Epub 2011 Aug 7.
OBJECTIVE
There is a paucity of data regarding relations of apolipoproteins (apolipoprotein B [ApoB] and apolipoprotein A-1 [Apo A-1]), lipoprotein particle measures (low-density lipoprotein particle concentration [LDLp] and high-density lipoprotein particle concentration [HDLp]), and lipoprotein cholesterol measures (low-density lipoprotein cholesterol [LDL-C], non-high-density lipoprotein cholesterol [non-HDL-C], and high-density lipoprotein cholesterol [HDL-C]) with atherosclerotic plaque burden, plaque eccentricity, and lipid-rich core presence as a marker of high-risk plaques.
METHODS
Carotid artery magnetic resonance imaging was performed in 1670 Atherosclerosis Risk in Communities study participants. Vessel wall and lipid cores were measured; normalized wall index (NWI), standard deviation (SD) of wall thickness (measure of plaque eccentricity) were calculated; and lipid cores were detected in vessels with ≥ 1.5mm thickness. Fasting concentrations of cholesterol, ApoB and Apo A-1, and LDLp and HDLp were measured.
RESULTS
Measures of plaque burden (carotid wall volume, wall thickness, and NWI) were positively associated with atherogenic cholesterol and lipoproteins (p < 0.05 for total cholesterol, LDL-C, non-HDL-C, ApoB, and LDLp), but not with HDL-C, Apo A-1, or HDLp. SD of wall thickness was associated with total cholesterol (p 0.01) and non-HDL-C (p 0.02). Although measures of atherogenic or anti-atherogenic cholesterol or lipoprotein were not individually associated with detection of a lipid-rich core, their ratios (total cholesterol/HDL-C, non-HDL-C/HDL-C, and LDLp/HDLp) were associated with lipid-rich core presence (p ≤ 0.05).
CONCLUSION
Extent of carotid atherosclerosis is associated with atherogenic cholesterol and lipoproteins. Atherogenic/anti-atherogenic cholesterol or particle ratios were associated with presence of a detectable lipid-rich core.
目的
有关载脂蛋白（载脂蛋白 B [ApoB] 和载脂蛋白 A-1 [Apo A-1]）、脂蛋白颗粒测量（低密度脂蛋白颗粒浓度 [LDLp] 和高密度脂蛋白颗粒浓度 [HDLp]）以及脂蛋白胆固醇测量（低密度脂蛋白胆固醇 [LDL-C]、非高密度脂蛋白胆固醇 [非 HDL-C] 和高密度脂蛋白胆固醇 [HDL-C]）与动脉粥样硬化斑块负担、斑块偏心度和富含脂质核心的关系的数据很少。
方法
对 1670 名动脉粥样硬化风险社区研究参与者进行颈动脉磁共振成像。测量血管壁和脂质核心；计算标准化壁指数（NWI）和壁厚度标准差（测量斑块偏心度）；并在厚度≥1.5mm 的血管中检测脂质核心。测量胆固醇、ApoB 和 Apo A-1 以及 LDLp 和 HDLp 的空腹浓度。
结果
斑块负担（颈动脉壁体积、壁厚度和 NWI）与致动脉粥样硬化胆固醇和脂蛋白呈正相关（总胆固醇、LDL-C、非 HDL-C、ApoB 和 LDLp 均<0.05），但与 HDL-C、Apo A-1 或 HDLp 无关。壁厚度标准差与总胆固醇（p<0.01）和非 HDL-C（p<0.02）相关。尽管致动脉粥样硬化或抗动脉粥样硬化胆固醇或脂蛋白的测量值与富含脂质核心的检测均无单独相关性，但它们的比值（总胆固醇/HDL-C、非 HDL-C/HDL-C 和 LDLp/HDLp）与富含脂质核心的存在相关（p≤0.05）。
结论
颈动脉粥样硬化的程度与致动脉粥样硬化的胆固醇和脂蛋白有关。致动脉粥样硬化/抗动脉粥样硬化胆固醇或颗粒比值与可检测到的富含脂质核心的存在相关。
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