Instituto Federal do Triangulo Mineiro, Campus Patos de Minas, Brazil; Institute of Biosciences, UNESP (Universidade Estadual Paulista) Physical Activity and Aging Lab (LAFE), Campus Rio Claro, Brazil.
Institute of Biosciences, UNESP (Universidade Estadual Paulista) Physical Activity and Aging Lab (LAFE), Campus Rio Claro, Brazil; UTFPR, Federal University of Technology - Paraná (UTFPR), Campus Curitiba, Brazil; Department of Physical Education, Midwestern Parana State University (UNICENTRO), Guarapuava, Brazil.
Behav Brain Res. 2023 Feb 2;437:114126. doi: 10.1016/j.bbr.2022.114126. Epub 2022 Sep 24.
Vascular endothelial growth factor (VEGF) and platelets seem to reflect the Alzheimer's disease (AD) associated either with vascular impairment or disease. This study aimed to compare the circulating levels of VEGF and platelets between AD patients and healthy older adults.
Seventy-two older adults, divided in 40 older adults (Clinical Dementia Rating Scale - CDR = 0); and 32 Alzheimer's disease patients (clinically diagnosed - CRD = 1) participated in the present study. The groups were paired by sex, age, comorbidities and educational level. The primary outcomes included circulating plasma VEGF and platelet levels obtained by blood collection.
The VEGF levels were significantly different between the groups (p = 0.03), with having a large effect size ( η =18.15), in which the AD patients presented lower levels compared to healthy older adults. For platelets, the comparison showed a tendency to difference (p = 0.06), with a large effect size (η =12.95) between the groups.
The VEGF levels and the platelet numbers were reduced in AD patients, suggesting that angiogenic factors could be modified due to AD.
血管内皮生长因子 (VEGF) 和血小板似乎反映了与血管损伤或疾病相关的阿尔茨海默病 (AD)。本研究旨在比较 AD 患者和健康老年人之间循环 VEGF 和血小板水平。
72 名老年人，分为 40 名老年人（临床痴呆评定量表 - CDR = 0）和 32 名阿尔茨海默病患者（临床诊断 - CRD = 1）。这些组通过性别、年龄、合并症和教育水平进行配对。主要结果包括通过采血获得的循环血浆 VEGF 和血小板水平。
两组之间 VEGF 水平存在显著差异（p = 0.03），具有较大的效应量（η = 18.15），AD 患者的水平低于健康老年人。对于血小板，比较显示出差异的趋势（p = 0.06），两组之间的效应量较大（η = 12.95）。
AD 患者的 VEGF 水平和血小板数量降低，提示 AD 可能导致血管生成因子发生改变。
