2型糖尿病合并牙周炎患者与非糖尿病牙周炎患者的IgA水平：一项前瞻性临床研究
IgA Levels among Type 2 Diabetic and Non-Diabetic Patients with Periodontitis: A Prospective Clinical Study.
作者信息
Palwankar Pooja, Jain Saumya, Pandey Ruchi, Mahesh Shakila
机构信息
Department of Periodontology, Manav Rachna Dental College FDS, MRIIRS Faridabad, Haryana, India.
Department of Microbiology, Manav Rachna Dental College FDS, MRIIRS Faridabad, Haryana, India.
出版信息
Eur J Dent. 2023 Jul;17(3):823-827. doi: 10.1055/s-0042-1755616. Epub 2022 Sep 27.
OBJECTIVES
To estimate gingival crevicular immunoglobulin A(IgA) using enzyme-linked immunosorbent assay (ELISA) among type II diabetic patients with periodontitis.
MATERIALS AND METHODS
A non-randomized study was done of 40 periodontitis subjects with a mean age of 50 years and were recruited into two groups, Group A (Type II controlled diabetics with HbA1c < 7%) and Group B (non-diabetics with HbA1c between 4 and 6%). Both the groups underwent nonsurgical periodontal therapy (NSPT). The clinical parameters were recorded at baseline, 1, and 3 months. GCF sample was collected for the estimation of crevicular IgA at baseline and at 3 months.
STATISTICAL ANALYSIS
Results were analyzed using parametric tests paired -test and Student's -test for every assessment point. The level of significance was set at < 0.05.
RESULTS
Difference in IgA levels and clinical parameters was seen between diabetic and non-diabetic groups, which was statistically significant.
CONCLUSION
Changes in crevicular IgA levels in patients with diabetic periodontitis can be used as a novel biomarker in assessing the inflammatory status.
目的
采用酶联免疫吸附测定法（ELISA）评估II型糖尿病伴牙周炎患者龈沟液中的免疫球蛋白A（IgA）。
材料与方法
对40名平均年龄50岁的牙周炎患者进行了一项非随机研究，将其分为两组，A组（糖化血红蛋白<7%的II型糖尿病控制患者）和B组（糖化血红蛋白在4%至6%之间的非糖尿病患者）。两组均接受非手术牙周治疗（NSPT）。在基线、1个月和3个月时记录临床参数。在基线和3个月时收集龈沟液样本以评估龈沟IgA。
统计分析
对每个评估点的结果采用参数检验配对t检验和学生t检验进行分析。显著性水平设定为<0.05。
结果
糖尿病组和非糖尿病组之间IgA水平和临床参数存在差异，具有统计学意义。
结论
糖尿病性牙周炎患者龈沟IgA水平的变化可作为评估炎症状态的一种新型生物标志物。
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