Joshi Astha, Maddipati Sreedevi, Chatterjee Anirban, Lihala Ratika, Gupta Ankita
Department of Periodontics, Oxford Dental College, Bengaluru, Karnataka, India.
Indian J Dent Res. 2019 Jan-Feb;30(1):47-51. doi: 10.4103/ijdr.IJDR_215_17.
Periodontitis and diabetes mellitus share a bidirectional relationship. Resistin is an adipocytokine shown to be associated with type 2 diabetes mellitus. Hence, the present study aims to estimate the effect of non-surgical periodontal therapy (NSPT) on GCF resistin levels in healthy individuals with gingivitis and well controlled diabetics with periodontitis, and correlate the same with HbA1c levels of the diabetic subjects.
The present study was a comparative interventional trial set in Department of Periodontics, the Oxford Dental College, Bangalore. Forty subjects participated in the study and were divided into two groups; group I (healthy individuals with gingivitis) and group II (diabetic individuals with mild to moderate periodontitis). Periodontal parameters were assessed and GCF was collected and analysed for resistin before and 3 months after NSPT.
All the analysis was done using SPSS version 18. A P value of < 0.05 was considered statistically significant.
A significant difference was observed in GCF resistin concentrations between the two groups at baseline, wherein group II had significantly higher values. Following NSPT, there was a significant reduction in GCF resistin concentrations in both the groups, however intergroup comparison showed no difference in the amount of reduction. When all samples were analysed together, no significant correlation could be found between resistin and the parameters assessed.
Resistin levels are increased in diabetes related periodontitis. However, post treatment a similar response can be seen between healthy and well controlled diabetics. Hence, resistin can be used as an inflammatory biomarker for diabetes related periodontal disease.
牙周炎与糖尿病存在双向关系。抵抗素是一种脂肪细胞因子，已被证明与2型糖尿病有关。因此，本研究旨在评估非手术牙周治疗（NSPT）对患有牙龈炎的健康个体以及牙周炎病情得到良好控制的糖尿病患者龈沟液中抵抗素水平的影响，并将其与糖尿病受试者的糖化血红蛋白水平相关联。
本研究是在班加罗尔牛津牙科学院牙周病科进行的一项对比性干预试验。40名受试者参与了研究，分为两组；第一组（患有牙龈炎的健康个体）和第二组（患有轻度至中度牙周炎的糖尿病个体）。在进行NSPT之前和之后3个月，评估牙周参数，收集龈沟液并分析其中的抵抗素。
所有分析均使用SPSS 18版软件进行。P值<0.05被认为具有统计学意义。
两组在基线时龈沟液抵抗素浓度存在显著差异，其中第二组的值显著更高。NSPT后，两组龈沟液抵抗素浓度均显著降低，但组间比较显示降低量无差异。当对所有样本一起分析时，未发现抵抗素与所评估参数之间存在显著相关性。
在糖尿病相关性牙周炎中抵抗素水平升高。然而，治疗后在健康个体和病情得到良好控制的糖尿病患者之间可以观察到类似的反应。因此，抵抗素可作为糖尿病相关性牙周疾病的一种炎症生物标志物。
