Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Department of Orthopedics, First Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
BMJ Open. 2022 Sep 27;12(9):e058568. doi: 10.1136/bmjopen-2021-058568.
Emotional disorders are often observed in inflammatory bowel disease (IBD). IBD with emotional disorders leads to poor quality of life. This systematic review aims to assess the effectiveness of acupuncture in patients with IBD with emotional disorders.
Nine electronic databases, including Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Allied and Complementary Medicine Database, Cumulative Index to Nursing & Allied Health Literature, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, VIP Database and Wanfang Database, will be searched from inception to October 2021 without language restriction. The grey literature containing conference proceedings, as well as systematic reviews listed in the reference of definite publications, will also be retrieved. Randomised controlled trials either in English or Chinese reporting acupuncture therapy for IBD with emotional disorders will be included. The primary outcome is changes of emotional functioning outcomes. The Colitis Activity Index, Crohn's Disease Activity Index, C reactive protein and adverse events will be assessed as the secondary outcomes. More than two assessors will conduct the study retrieval and selection, as well as the data extraction and evaluation of the risk of bias. Data synthesis will be performed using a random-effects model based on the results of heterogeneity. Data analysis will be performed using RevMan software (V.5.4). Moreover, the dichotomous data will be presented as risk ratios, and the continuous data will be calculated using weighted mean difference or standard mean difference.
This systematic review contains no individual patient data; thus, ethical approval is not required. Moreover, this review will be disseminated in a peer-reviewed journal or relevant conference.
CRD42020176340.
炎症性肠病（IBD）常伴有情绪障碍。伴有情绪障碍的 IBD 会导致生活质量下降。本系统评价旨在评估针刺治疗伴有情绪障碍的 IBD 患者的有效性。
从建库至 2021 年 10 月，我们将检索 9 个电子数据库，包括 Cochrane 对照试验中心注册库、MEDLINE、EMBASE、补充和综合医学数据库、护理学及相关健康文献累积索引、中国知网、中国生物医学文献数据库、维普数据库和万方数据库，检索时不限制语言。我们还将检索包含会议论文集的灰色文献，以及在确定出版物参考文献中列出的系统评价。我们将纳入英语或中文报告针刺治疗伴有情绪障碍的 IBD 的随机对照试验。主要结局是情绪功能结局的变化。次要结局包括结肠炎活动指数、克罗恩病活动指数、C 反应蛋白和不良事件。将由 2 名以上评估员进行研究检索和选择，以及数据提取和偏倚风险评估。基于异质性结果，将使用随机效应模型进行数据分析。数据分析将使用 RevMan 软件（V.5.4）进行。此外，二分类数据将表示为风险比，连续数据将使用加权均数差或标准均数差进行计算。
本系统评价不包含个体患者数据，因此不需要伦理批准。此外，本综述将发表在同行评议的期刊或相关会议上。
PROSPERO 注册号：CRD42020176340。
