Department of Microbiology & Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, United States.
Department of Microbiology & Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, United States.
Adv Microb Physiol. 2022;81:111-135. doi: 10.1016/bs.ampbs.2022.06.003. Epub 2022 Jul 23.
Staphylococcus aureus is an important human pathogen causing a wide range of disease presentations. It harbors a vast array of virulence factors and drug-resistance determinants. All of these factors are coordinately regulated by a hand full of key transcriptional regulators. The regulation and expression of these factors are tightly intertwined with the metabolic state of the cell. Furthermore, alterations in central metabolism are also key to the ability of S. aureus to resist clearance by the host innate immune response, including nitric oxide (NO·) production. Given the fact that central metabolism directly influences virulence, drug resistance and immune tolerance in S. aureus, a better understanding of the metabolic capabilities of this pathogen is critical. This work highlights some of the major findings within the last five years surrounding S. aureus central metabolism, both organic and inorganic. These are also put in the context of the unique NO·-resistance associated with this pathogen as well as their contributions to virulence. The more we understand the intersection between central metabolism and virulence capabilities in S. aureus, the better the chances of developing novel therapeutics so desperately needed to treat this pathogen.
金黄色葡萄球菌是一种重要的人类病原体，可引起多种疾病。它拥有大量的毒力因子和耐药决定因素。所有这些因素都由少数关键转录调节剂协调调节。这些因素的调节和表达与细胞的代谢状态紧密交织在一起。此外，中心代谢的改变也是金黄色葡萄球菌抵抗宿主固有免疫反应清除的关键，包括一氧化氮（NO·）的产生。鉴于中心代谢直接影响金黄色葡萄球菌的毒力、耐药性和免疫耐受性，更好地了解这种病原体的代谢能力至关重要。这项工作强调了过去五年中围绕金黄色葡萄球菌中心代谢（有机和无机）的一些主要发现。这些发现也与该病原体与一氧化氮（NO·）耐药性相关以及它们对毒力的贡献有关。我们对金黄色葡萄球菌中心代谢和毒力能力之间的交叉点了解得越多，就越有机会开发出急需的新型疗法来治疗这种病原体。
