Department of Ophthalmology, Kangdong Sacred Heart Hospital, 150, Seongan-Ro, Gangdong-Gu, Seoul, 05355, South Korea.
Sci Rep. 2022 Sep 27;12(1):16069. doi: 10.1038/s41598-022-20423-0.
This study aimed to compare the rate of thinning between retinal nerve fiber layer thickness (RNFLT) and Bruch's membrane opening minimum rim width (BMO-MRW) in open-angle glaucoma (OAG) according to glaucoma severity. We retrospectively reviewed subjects with a total of 111 eyes with OAG that had undergone optical coherence tomography more than four times during more than 3 years of follow-up. The subjects were divided into three groups based on the mean deviation (MD) of the baseline visual field test: high MD (MD > - 2 dB), medium MD (- 2 dB ≥ MD > - 6 dB), and low MD (- 6 dB ≥ MD > - 12 dB) groups. A linear mixed model was employed to compare the rate of thinning between RNFLT and BMO-MRW among the three groups. The rate of RNFLT thinning was fastest in the inferotemporal sector in all three groups. The rate of BMO-MRW thinning was fastest in the inferotemporal sector of the high MD group and the superotemporal sector of the other two groups. Among the three groups, the rate of RNFLT thinning was not significantly different in the global sector and all sectors except the nasal sector. The rate of BMO-MRW thinning in the inferotemporal sector showed no significant difference, but that in the superotemporal sector was faster in the medium MD and low MD groups than in the high MD group. The fastest rate of RNFLT thinning was consistently observed in the inferotemporal sector, but BMO-MRW showed a change in the fastest thinning sector from inferotemporal to superotemporal, with increasing severity in early to moderate OAG. The difference in the changes in the two parameters may help understand the pathogenesis of glaucoma and predict its progression.
本研究旨在比较开角型青光眼（OAG）根据严重程度，神经纤维层厚度（RNFLT）和Bruch 膜开口最小边缘宽度（BMO-MRW）变薄的速度。我们回顾性分析了 111 只患有 OAG 的眼，这些眼在超过 3 年的随访中接受了超过 4 次光学相干断层扫描。根据基线视野测试的平均偏差（MD），将这些眼分为三组：高 MD（MD＞-2dB）、中 MD（-2dB≥MD＞-6dB）和低 MD（-6dB≥MD＞-12dB）。采用线性混合模型比较三组之间 RNFLT 和 BMO-MRW 的变薄速度。在三组中，所有象限中颞侧象限的 RNFLT 变薄速度最快。高 MD 组的颞下象限和其他两组的颞上象限的 BMO-MRW 变薄速度最快。在三组中，除了鼻侧，全局和所有象限的 RNFLT 变薄速度均无显著差异。颞下象限的 BMO-MRW 变薄速度没有明显差异，但中 MD 和低 MD 组的颞上象限的变薄速度比高 MD 组快。RNFLT 始终在颞下象限观察到最快的变薄速度，但 BMO-MRW 从颞下象限变为颞上象限，随着早期到中度 OAG 的严重程度增加而显示出最快的变薄区域。这两个参数变化的差异可能有助于了解青光眼的发病机制并预测其进展。
