人眼对球镜变化分辨率极限的理论推导和临床验证：一项自身对照研究。
Theoretical derivation and clinical validation of the resolution limit of human eye to spherical lens change: a self-controlled study.
机构信息
National Engineering Research Center for Ophthalmology, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang, Beijing, 100730, Dongcheng, China.
Key Laboratory of Sichuan Province Ophthalmopathy Prevention & Cure and Visual Function Protection With TCM, Eye School of Chengdu University of TCM, Jinniu District, No. 8, Xinghui West Road, Chengdu, 610084, China.
出版信息
Int Ophthalmol. 2023 Apr;43(4):1387-1394. doi: 10.1007/s10792-022-02538-5. Epub 2022 Sep 27.
PURPOSE
The aim of this study was to deduce theoretically and verify the resolution limit of human eye to spherical lens change for more reasonable design of the trial lenses.
METHODS
A total of 119 normal subjects with different myopia (not more than - 6D) were included. First, the resolution limit of discernible change in spherical power was derived based on the optical model. Then, the subjects were observed to see if they could perceive the changes in spherical power as per the resolution limit and compare the difference in the best-corrected visual acuity obtained with the resolution limit and interval of 0.25D.
RESULTS
Assuming that the cone cell diameter is 3 μm and the pupil diameter of 4 mm, the theoretically resolution limit was 0.05D. When the diopter of spherical power was increased, the ratios of ability to perceive 0.05D spherical lens change were 98.3% and 96.7% in right and left eyes. When the diopter of spherical power was decreased, the ratios of ability to perceive 0.05D spherical lens change were 78.9% and 83.2% in right and left eyes. The best-corrected visual acuity obtained with the 0.05 D interval trial lens was significantly better than in the 0.25 D interval on both eyes (Right eye - 0.04 ± 0.07 vs - 0.02 ± 0.06, p < 0.001; Left eye - 0.07 ± 0.06 vs - 0.04 ± 0.06, t = 8.825, p < 0.001).
CONCLUSION
The resolution limit of human eye to spherical lens change was about 0.05D and the better corrected visual acuity can be obtained by adjusting the spherical power at an interval of 0.05D.
TRIAL REGISTRATION NUMBER
ChiCTR2100047074. Date of registration: 2021/6/7.
目的
本研究旨在从理论上推导并验证人眼对球镜变化的分辨力极限，以更合理地设计试验镜片。
方法
共纳入 119 名不同近视程度（不超过-6D）的正常受试者。首先，基于光学模型推导出可分辨的球镜屈光力变化的分辨力极限。然后，观察受试者是否能够感知到符合分辨力极限的球镜屈光力变化，并比较使用分辨力极限和 0.25D 间隔获得的最佳矫正视力的差异。
结果
假设视锥细胞直径为 3μm，瞳孔直径为 4mm，理论分辨力极限为 0.05D。当球镜屈光力增加时，右眼和左眼感知 0.05D 球镜变化的能力比例分别为 98.3%和 96.7%。当球镜屈光力减小时，右眼和左眼感知 0.05D 球镜变化的能力比例分别为 78.9%和 83.2%。使用 0.05D 间隔试验镜片获得的最佳矫正视力明显优于 0.25D 间隔（右眼：-0.04±0.07 与-0.02±0.06，p<0.001；左眼：-0.07±0.06 与-0.04±0.06，t=8.825，p<0.001）。
结论
人眼对球镜变化的分辨力极限约为 0.05D，通过以 0.05D 的间隔调整球镜屈光力，可以获得更好的矫正视力。
临床试验注册号
ChiCTR2100047074。注册日期：2021/6/7。
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