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Heterozygous Variants in the DNA-binding Domain of c-Myb May Affect Normal B/T Cell Development.

作者信息

Smits Bas M, Hartley Taila, Dünnebach Ester, Bartels Marije, Boycott Kim M, Kernohan Kirstin D, Dyment David A, Giltay Jacques C, Haddad Elie, Jarinova Olga, van Montfrans Joris, van Royen-Kerkhof Annet, van der Veken Lars T, de Witte Moniek, Nierkens Stefan, Pham-Huy Anne, Leavis Helen L

机构信息

Department of Pediatric Immunology and Infectious Diseases, Utrecht University, University Medical Center (UMC) Utrecht, The Netherlands.

Center for Translational Immunology, Utrecht University, University Medical Center (UMC) Utrecht, The Netherlands.

出版信息

Hemasphere. 2022 Sep 21;6(10):e774. doi: 10.1097/HS9.0000000000000774. eCollection 2022 Oct.

DOI:10.1097/HS9.0000000000000774
PMID:36168523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9509140/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78db/9509140/ea8935dc1ece/hs9-6-e774-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78db/9509140/ea8935dc1ece/hs9-6-e774-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78db/9509140/ea8935dc1ece/hs9-6-e774-g001.jpg

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Heterozygous Variants in the DNA-binding Domain of c-Myb May Affect Normal B/T Cell Development.c-Myb 蛋白 DNA 结合结构域中的杂合变异可能影响正常 B/T 细胞发育。
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Inhibition of cyclin A/Cdk2 phosphorylation impairs B-Myb transactivation function without affecting interactions with DNA or the CBP coactivator.细胞周期蛋白A/细胞周期蛋白依赖性激酶2磷酸化的抑制会损害B-Myb反式激活功能,而不影响其与DNA或CBP共激活因子的相互作用。
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本文引用的文献

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Human Inborn Errors of Immunity: 2022 Update on the Classification from the International Union of Immunological Societies Expert Committee.人类先天性免疫缺陷:国际免疫学联盟专家委员会 2022 年更新的分类。
J Clin Immunol. 2022 Oct;42(7):1473-1507. doi: 10.1007/s10875-022-01289-3. Epub 2022 Jun 24.
2
Rubella Virus Infected Macrophages and Neutrophils Define Patterns of Granulomatous Inflammation in Inborn and Acquired Errors of Immunity.风疹病毒感染的巨噬细胞和中性粒细胞定义了先天性和获得性免疫缺陷相关的肉芽肿性炎症模式。
Front Immunol. 2021 Dec 20;12:796065. doi: 10.3389/fimmu.2021.796065. eCollection 2021.
3
Circular RNA circVAPA contributes to non-small-cell lung cancer progression via miR-342-3p-dependent regulation of ZEB2.
环状 RNA circVAPA 通过 miR-342-3p 依赖的 ZEB2 调控促进非小细胞肺癌进展。
World J Surg Oncol. 2021 Nov 29;19(1):335. doi: 10.1186/s12957-021-02447-4.
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Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis.环状 RNA3823 通过 miR-30c-5p/TCF7 轴促进结直肠癌细胞的生长、转移和血管生成。
Mol Cancer. 2021 Jun 25;20(1):93. doi: 10.1186/s12943-021-01372-0.
5
Regulatory effect of the MAFG‑AS1/miR‑150‑5p/MYB axis on the proliferation and migration of breast cancer cells.MAFG-AS1/miR-150-5p/MYB 轴对乳腺癌细胞增殖和迁移的调控作用。
Int J Oncol. 2021 Jan;58(1):33-44. doi: 10.3892/ijo.2020.5150. Epub 2020 Nov 20.
6
Recognizing a Non-classical Telomeropathy before Hematopoietic Stem Cell Transplantation in Pediatric Patients: A Case Series.在儿科患者造血干细胞移植前识别非典型端粒病:病例系列
Hemasphere. 2019 Aug 7;3(4):e282. doi: 10.1097/HS9.0000000000000282. eCollection 2019 Aug.
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Clin Immunol. 2020 Mar;212:108248. doi: 10.1016/j.clim.2019.108248. Epub 2019 Aug 2.
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Nat Immunol. 2019 Mar;20(3):337-349. doi: 10.1038/s41590-018-0311-z. Epub 2019 Feb 18.
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