Sezer Hüseyin Fatih, Eliçora Aykut
Department of Thoracic Surgery, Kocaeli University Faculty of Medicine, Kocaeli, Türkiye.
Turk Gogus Kalp Damar Cerrahisi Derg. 2022 Apr 27;30(2):206-215. doi: 10.5606/tgkdc.dergisi.2022.21303. eCollection 2022 Apr.
This study aims to investigate long-term results related to N1 group metastases with respect to anatomical localization and many external parameters and to examine the effect of these parameters on prognosis in patients with in nonsmall cell lung cancer.
Between January 2006 and May 2019, a total of 52 patients (44 males, 8 females; mean age: 59.9±9.5 years; range, 42 to 80 years) who underwent lobectomy due to primary lung malignancy were retrospectively analyzed. The N1 lymph nodes were divided into three anatomical groups as hilar, peribronchial, and intraparenchymal. Demographic features, tumor features, follow-up characteristics, and survival and diseasefree survival parameters were analyzed for each group. The results were also examined in terms of number of metastasis, number of metastatic levels, rate of metastasis, and histopathological type.
The five-year survival rate was 66.4% in the peribronchial group and 50% in the hilar group. The five-year disease-free survival rate was 45.7% in the peribronchial group and 37.5% in the hilar group. There was no statistically significant difference between the groups in terms of survival and disease-free survival for anatomical localization, number of metastasis, number of metastatic levels, rate of metastasis, and histopathological type (p>0.05 for all).
The structure that would be formed by examining N1 in terms of parameters such as subtitle levels, number of metastasis, number of metastatic stations, rate of metastasis or combinations of these would have a more impact on the decisions in the follow-up and treatment process in this patient population.
本研究旨在探讨非小细胞肺癌患者中与N1组转移相关的长期结果，涉及解剖定位和许多外部参数，并研究这些参数对预后的影响。
回顾性分析2006年1月至2019年5月间因原发性肺恶性肿瘤接受肺叶切除术的52例患者（44例男性，8例女性；平均年龄：59.9±9.5岁；范围42至80岁）。N1淋巴结被分为肺门、支气管周围和实质内三个解剖学组。对每组患者的人口统计学特征、肿瘤特征、随访特征以及生存和无病生存参数进行分析。还从转移数量、转移层数、转移率和组织病理学类型方面对结果进行了研究。
支气管周围组的五年生存率为66.4%，肺门组为50%。支气管周围组的五年无病生存率为45.7%，肺门组为37.5%。在解剖定位、转移数量、转移层数、转移率和组织病理学类型方面，两组之间的生存和无病生存无统计学显著差异（所有p>0.05）。
根据亚组水平、转移数量、转移站数量、转移率或这些因素的组合等参数来检查N1所形成的结构，对该患者群体随访和治疗过程中的决策影响更大。
