Sasaki I, Tuchiya T, Naito H, Funayama Y, Toda M, Suzuki Y, Sato T, Ohneda A
Tohoku J Exp Med. 1987 Apr;151(4):419-28. doi: 10.1620/tjem.151.419.
The effect of ileo-jejunal transposition (IJT) on the intestinal adaptation after total colectomy was investigated in 4 mongrel dogs. Hyperenteroglucagonemia was observed in the IJT with colectomy group, especially in postprandial state. Obvious hyperplastic changes were observed in all part of the small intestinal mucosa in the colectomy with IJT group. However, there were no significant differences in body weight changes between the colectomy with IJT group and the colectomy group. Postprandial plasma gastrin levels were lower in the colectomy with IJT group compared to the control. These results suggest that IJT causes hyperenteroglucagonemia and intestinal mucosal hypertrophy in colectomized dogs. Enteroglucagon may have an inhibitory effect on postprandial gastrin release.
在4只杂种犬中研究了回肠-空肠转位（IJT）对全结肠切除术后肠道适应性的影响。在IJT联合结肠切除组中观察到高肠高血糖素血症，尤其是在餐后状态。在IJT联合结肠切除组中，小肠黏膜各部位均观察到明显的增生性变化。然而，IJT联合结肠切除组与结肠切除组之间的体重变化无显著差异。与对照组相比，IJT联合结肠切除组餐后血浆胃泌素水平较低。这些结果表明，IJT可导致结肠切除犬出现高肠高血糖素血症和肠黏膜肥大。肠高血糖素可能对餐后胃泌素释放有抑制作用。
